Information about Vinflunine tartrate

Name: Vinflunine
Chemical Synonyms: VINFLUNINE; 20 ', 20'-Difluoro-3', 4'-dihydrovinorelbine; 4'-Deoxy-20 ', 20'-difluoro-5'-norvincaleukoblastine; 4'-Deoxy-20', 20'-difluoro-8'-norvincaleukoblastine; Vinflunine Tartrate
CAS No.: 162652-95-1
Formula: C45H54F2N4O8
Molecular Weight: 816.93

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From:pharmaceutical chemicals

A brief introduction CD4 ELISA Kit

CD4 cells are a kind of important immune cells in the body's immune system, CD4 expression mainly in T helper (Th) cells, is Th cell TCR identify antigen for the receptor, the peptide section with MHC class Ⅱ molecules combined with, participate in Th cell antigen which is the identification of signal transduction, CD4 receptors and HIV, the AIDS virus attacks object is CD4 cells, so the test result on the immune function of patients with AIDS treatment effect of judgment, and to the important role in the judgment.

Normal adult CD4 cells per cubic millimeter in 500 to 1600, HIV infection of CD4 cells developed progressive or irregularity decline, marked the immune system is severely damaged, when CD4 cells per cubic millimeter less than 200 a, may be a variety of opportunistic infection or tumor.

Principle of HIV/AIDS infection: white blood cells are killing foreign microbe guardians of the human body, it mainly contains the CD4 and CD8 and CD4 cells play the role of "informant", CD8 cells is engulf bacteria, when AIDS virus enters the body, it will be abducted CD4 cells, CD8 cells become "the blind and the deaf", HIV invades white blood cells, then the white blood cells as their own breeding hotbed.

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What are the side effects Valporic Acid kit

A multitude of antiepileptic drugs in current valproic acid is a wide clinical application, high curative effect and safety of good choice, broad spectrum drugs. Valproic acid (DE ba jin? Not only can be used to treat various kinds of epilepsy of generalized seizures, especially the absence seizure and stiffness - clonus attack, can also be used for partial onset seizures.

Side effects: compared with carbamazepine and valproic acid has obvious tremor and weight gain effects, but less rash. The acute side effects of valproic acid, mainly (see more oral dosage forms) reaction of gastrointestinal tract and tremors. Tremor is a mild excessive performance, reduce the dose can be controlled.

Valproic acid varied chronic toxicity reaction performance. The most common is weight gain, high blood ammonia is common, but for most patients with no clinical significance. Treatment dose valproic acid will not affect cognitive function, unless you use high doses.

Atopic side effects are rare, but the risk is bigger. Thrombocytopenia associated with dose, and the severity of the surgical research shows that thrombocytopenia has nothing to do with bleeding; The incidence of pancreatitis is about 1/40 of 000; The incidence of hepatitis is about 1/10 1/40 000 ~ 000. In recent years, with the overall understanding of the risk factors, as well as the strict monitoring measures taken, did not have any reports of deaths due to pancreatitis or hepatitis.

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From:Natural herbal extracts

What is phenol?

Phenol, also known as carbolic acid, hydroxy benzene, German chemist Runge Runge (F) in 1834, found in coal tar, is one of the most simple phenols, organic matter a weak acid. Room temperature for a colorless crystals, are poisonous. Phenol is a kind of common chemicals, the production of certain resin, fungicides, preservatives and important raw material of drugs (eg, aspirin). Phenol corrosive, room temperature slightly soluble in water, soluble in organic solvents. When the temperature higher than 65 ℃, can with water in any proportion miscibility. Stick to its solution available alcohol washing on the skin, the pink phenol exposed to air.

Main application:

Important organic synthetic raw material, for making phenolic resin and bisphenol A, phenolphthalein, picric acid, salicylic acid, alkyl phenol and other chemicals, also can be used as A solvent. Widely used in the manufacture of phenolic resin, epoxy resin, polyamide fiber, plasticizer, developer, preservatives, pesticides, fungicides, dye, medicine, spices, explosive and so on.

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The introduction of the Corticosteroids ELISA Kit

Corticosteroids are made by the adrenal cortex and steroid hormone secretion, also can through the synthetic. Its pharmacological effects and complex, and widely involved in physical systems, such as the stress response, the immune response, and inflammation, carbohydrate metabolism, protein catabolism, control of electrolyte concentration in the blood.

Corticosteroids are cholesterol as raw materials synthesized in the adrenal cortex. Most of the steroid reaction must be catalyzed by cytochrome P450 enzymes. It inside the iron REDOX proteins to mitochondria as a cofactor (except 21 hydroxylase and 17 alpha hydroxylase).

The biosynthetic pathways of aldosterone and corticosterone in the first part of the same, the bottom part respectively by aldosterone synthase and 11 beta hydroxylase intermediary. These two enzymes are very similar, are able to do 11 beta hydroxy and 12 - hydroxy role, but also to 18 - oxidation. In addition, aldosterone synthase exist in the ball of the outside of the adrenal cortex; 11 beta hydroxylase are visible to zona fasciculata and zona.

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The basic information of the Vinflunine tartrate

English name: Vinflunine Tartrate

English synonyms:

CAS no. : 1201898-17-0

Molecular formula: C45H54F2N4O8 xC4H6O6

Molecular weight: 0

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From:pharmaceutical chemicals

The application of Bitumen

Bitumen is hydrophobic material, it impermeable, almost insoluble in water, dilute ethanol, acetone, ether, soluble in carbon disulfide, carbon tetrachloride, sodium hydroxide. Health hazard: medium toxicity. Asphalt and flue gas of skin mucous membrane irritation, has the light effect and the effect that cause cancer. China's three major asphalt toxicity: coal tar > > oil shale asphalt asphalt, before both have carcinogenicity. The main skin lesions are: asphalt light contact dermatitis, skin confined to the face, neck and other exposed parts; Melanosis, skin lesions often symmetrical distributed in the exposed parts, plate shaped, brown - deep brown - brown-black; Occupational acne; Verrucous vegetations and the accident cause thermal burns. In addition, there are dizziness, head bilges, headache, chest tightness, fatigue, nausea, loss of appetite and other systemic symptom and eye, nose, pharynx and irritation.

Application: in civil engineering, bitumen is waterproof materials and widely used anticorrosion material, mainly used in roofing, ground, underground waterproof structure, wood, steel corrosion. Or road asphalt pavement cementing materials applied widely in engineering, and it has to do with different composition of mineral materials in proportion with different structure of asphalt pavement can be built.

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The introduction of the zafirlukast

Zafirlukast, as a kind of polypeptide LTC4, LTD4 and LTE4 allergic reactions such as slow reaction substance leukotriene receptor antagonist, competitive inhibition activity of leukotriene, effectively prevent leukotriene polypeptide of the increase in vascular permeability caused by airway edema, and inhibition of leukotriene polypeptide produced by airway eosinophilia cell infiltration, reduce tracheal contraction and inflammation, relieve asthma symptoms. Drugs are highly selective and only ACTS on leukotriene receptor, does not affect the prostaglandins, thromboxane, cholinergic and histamine receptor. Good oral absorption, after about 3 h peak plasma concentration. Medication within 2 h, drug plasma concentration has yet to reach the peak can be produced in the base bronchial exercise tension first agent effect obviously. Plasma protein combined rate of 99%, urinary excretion is 10% of the oral dose, stool excretion was 89%, the elimination half-life of about 10 h. Pharmacokinetic no significant differences in the normal people and patients with renal damage. Take with food when the majority of patients (75%) of reduced bioavailability, the reduction of 40%.

In asthma pathophysiology of the disease, think leukotriene product (LT) and its receptor to produce including the effect of smooth muscle contraction, airway edema and inflammatory cells activity changes (such as acidophilic cell lung infiltrates) are associated with the signs and symptoms of asthma. Drug as an anti-inflammatory drug, can reduce the inflammatory mediators. Drugs as a strong oral peptide LTC4, LTD4 and LTE4 allergic reactions such as slow reaction substance leukotriene receptor antagonist, belong to the competitive inhibition, has the characteristics of high selectivity. In vitro studies have shown that this drug antagonism in the human body the conduction of all three leukotriene polypeptide contraction of airway smooth muscle activity (leukotriene C4, D4 and E4), and the same degree. Animal experiments showed that the effect of drugs mainly: effectively prevent leukotriene peptides due to increased vascular permeability, which can cause airway edema; Inhibition of leukotriene polypeptide produced by airway eosinophilia cell infiltration. Clinical studies also demonstrated the specificity of the drug, only on leukotriene receptor, but does not affect the prostaglandins, thromboxane and histamine and acetylcholine receptors. , according to the verified by clinical medicine with anti-inflammatory properties, 5 doses of the drug can reduce airway cells caused by antigen stimulation and non cell inflammatory substances. Placebo-controlled study found that the antigens stimulate 48 hr after bronchoalveolar lavage, zafirlukast over, inhibit acidophilic cells, lymphocytes, and the rise of tissue cells, and to reduce the alveolar macrophage stimulation produced by peroxide. Drugs can inhibit airway hyperresponsiveness antigen stimulate and platelet active factor cause bronchospasm.

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From:Natural herbal extracts

Information about Quinolinic acid

Quinolinic acid is a byproduct of the kynurenine pathway, which is amenable for catabolism of tryptophan in mammals. This alleyway is important for its assembly of the coenzyme nicotinamide adenine dinucleotide (NAD+) and produces several neuroactive intermediates including quinolinic acid, kynurenine (KYN), kynurenic acerbic (KYNA), 3-hydroxykynurenine (3-HK), and 3-hydroxyanthranilic acerbic (3-HANA).Quinolinic acid's neuroactive and excitatory backdrop are a aftereffect of NMDA receptor agonism in the brain. It aswell acts as a neurotoxin, gliotoxin, proinflammatory mediator, and pro-oxidant molecule.
Quinolinic acid is clumsy to canyon through the blood-brain barrier (BBB) and accept to be produced aural the academician microglial beef or macrophages that accept anesthetized the BBB.While  Quinolinic acid  cannot canyon the BBB, kyurenic acid, tryptophan and 3-hydroxykynurenine do and after act as precursors to the assembly of  Quinolinic acid  in the brain. The  Quinolinic acid  produced in microglia is again appear and stimulates NMDA receptors consistent in excitatory neurotoxiticity.While astrocytes are not able to aftermath  Quinolinic acid  directly, they are able of bearing KYNA, which if appear from the astrocytes can be taken in by migroglia that can in about-face access  Quinolinic acid  production.

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From:Natural herbal extracts

Information about 3-Cyano-4-methony-2-(1H)-pyridinone

English name: 4 - Methoxy - 2 - oxo - 1, 2 - dihydro - pyridine - 3 - carbonitrile

English synonyms: 4 - METHOXY - 2 - OXO - 1, 2 - DIHYDRO - 3 - PYRIDINECARBONITRILE; 4 - Methoxy - 2 - oxo - 1, 2 - dihydro - pyridine - 3 - carbonitrile; 3 - CYANO - 2 - HYDROXY - 4 - METHOXYPYRIDINE; 3-4 - methoxyl Cyano - - 2 - (1 h) - pyridione; 3 - CYANO - 4 - METHOXY - 2 - (1 h) - PYRIDINONE; 1, 2 - DIHYDRO - 4-2 - OXO - 3 - METHOXY - PYRIDINECARBONITRILE; AURORA KA - 6226. 3-4 - methoxy1 Cyano - - 2 - (1 h) - pyridione

CAS no. : 21642-98-8

Molecular formula: C7H6N2O2

Molecular weight: 150.13

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Information about teneligliptin

Dipeptidyl peptidase-4 (DPP-4) inhibitors accept afresh emerged as a new chic of antidiabetic that appearance favorable after-effects in convalescent glycemic ascendancy with a basal accident of hypoglycemia and weight gain. Teneligliptin, a atypical DPP-4 inhibitor, exhibits a different anatomy characterized by 5 afterwards rings, which aftermath a almighty and abiding effect. Teneligliptin is currently acclimated in cases assuming bereft advance in glycemic ascendancy even afterwards diet ascendancy and exercise or a aggregate of diet control, exercise, and sulfonylurea- or thiazolidine-class drugs. In adults, teneligliptin is orally administered at a dosage of 20 mg already daily, which can be added up to 40 mg per day. Because the metabolites of this biologic are alone via renal and hepatic excretion, no dosage acclimation is all-important in patients with renal impairment. The assurance contour of teneligliptin is agnate to those of added accessible DPP-4 inhibitors. However, attention needs to be acclimatized if administering teneligliptin to patients who are decumbent to QT prolongation. One abstraction has appear that the postprandial claret glucose-lowering furnishings of teneligliptin administered above-mentioned to breakfast were abiding throughout the day, and the furnishings empiric afterwards banquet were agnate to those empiric afterwards breakfast or lunch. Thus, although analytic abstracts for this new biologic are limited, this biologic shows affiance in stabilizing glycemic fluctuations throughout the day and appropriately suppressing the progression of diabetic complications. However, connected appraisal in abiding studies and analytic trials is appropriate to appraise the ability and assurance of the biologic as able-bodied as to analyze added break for its analytic use.

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Hyodeoxycholic acid is a kind of ursodeoxycholic acid

Hyodeoxycholic acid is extracted from pig bile a ursodeoxycholic acid. Can inhibit the formation of bile acid and dissolved fat, lower cholesterol and triglycerides in the blood, suitable for Ⅰ type a or b Ⅰ hyperlipidemia, sclerosis of arterial congee appearance. To bordetella pertussis, diphtheria bacillus, staphylococcus aureus, etc have certain bacteriostasis. Can be used as an anti-inflammatory drugs, the treatment of chronic bronchitis, infantile viral upper respiratory tract inflammation, etc. This product can stimulate the secretion of bile, bile is thinning and not increase the solids, applicable to biliary tract infection, cholecystitis, cholelith disease, and other non obstructive cholestasis; Can also accelerate the gallbladder contrast agent for liver and contribute to development. Can promote the intestinal fat decomposition and fat-soluble vitamins absorption, can be used in the liver and gallbladder disorders cause indigestion, can reduce cholesterol in the blood at the same time, the treatment and prevention of coronary heart disease, high blood pressure, etc

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Ciprofloxacin hydrochloride treatment of infection

Ciprofloxacin hydrochloride for prescription drugs. Used for urinary reproductive system caused by sensitive bacteria infection, including simple and complicated urinary tract infection, bacterial prostatitis, bacteria neisseria gonorrhea urethritis and cervicitis (including enzyme production strains caused by). Respiratory tract infections, including sensitive acute bronchial infection caused by gram-negative bacilli and lung infection. Gastrointestinal tract infection by shigella, salmonella, produce enterotoxin e. coli, moisture, deputy hemolytic bacterium vibrio, etc. The treatment of typhoid bone and joint infection, skin soft tissue infection, septicemia and systemic infection.

Used for 1. Caused by sensitive bacteria urinary reproductive system infection, including simple and complicated urinary tract infection, bacterial prostatitis, bacteria neisseria gonorrhea urethritis and cervicitis (including enzyme production strains caused by). 2. Respiratory tract infection, including sensitive acute bronchial infection caused by gram-negative bacilli and lung infection. 3. The gastrointestinal tract infection by shigella, salmonella, produce enterotoxin e. coli, moisture, deputy hemolytic bacterium vibrio, etc. 4. Typhoid. 5. Bone and joint infections. 6. The skin soft tissue infection. 7. Sepsis systemic infection, etc. The chemical composition  ciprofloxacin hydrochloride. Its chemical name: l - cyclopropyl - 6 - fluoro - 1, 4, 2 hydrogen. 4. Oxygen generation - 7 - (1 - piperazine) - 3 - quinoline carboxylic acid hydrochloride formula: C17H18FN3O3, HCl, and H2O.

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The classification of the Germanium Sesquioxide Organic USP

The influence of germanium on the human body is mainly can restore fatigue; To prevent anemia; Help the metabolism and so on. Many places are treated as medical auxiliary equipment. But without clinical proved to be effective. That is most will say: the body will be lighter, the pain will reduce, and so on. If taking, there have been examples of death. Clinical researchers believe that there is a dangerous thing. Will have bad effect to the kidney. But in Japan, in the jewelry industry is regarded as a health utensils in a necklace, bracelet in selling. The price does not poor.

Is divided into categories: organic germanium synthetic organic germanium, natural organic germanium, biological organic germanium three categories. Synthesis of organic germanium is half as many hydroxyethyl germanium oxide, namely, Ge - 132, screw germanium, furan germanium derivatives such as antiviral, anti-inflammatory, anti-cancer, organic germanium, is a compound of extensive pharmacological effects, but taking too much easy to cause calcium deficiency; Made of natural plant extract, natural organic germanium or eaten, to the human body without any side effects; Biological organic germanium is planted germanium compounds organisms, such as yeast, bacteria, fungus, vegetables, etc. Organic germanium compounds inhibit tumor activity possible mechanisms including enhancing immunity, scavenging free radicals and multiple aspects, such as resistance mutations. Many bioactive molecule organic germanium compounds, coordination with germanium atoms are usually oxygen, sulfur and nitrogen of high voltage negative atoms, due to their electronic absorption germanium atoms around the electron cloud of deviating from the nucleus to form a positive center. But organic germanium compounds in tumor cells and normal center can increase the potential of tumor cells, reduce its activity ability, which have the effect of restrain and kill tumor cells, which means that organic germanium compounds to inhibit the activity of tumor biological potential theory. [1]

Natural organic germanium is one of the ingredients of many medicinal plants, ginseng and other medicinal plants are rich in organic germanium, has a unique health functions. Since 1971, the Japanese scholar shallow Wells, kazuhiko synthesized by hydroxyethyl half as many germanium oxide (GeCH2COOH) 203, referred to as "Ge - 132, and proved its anti-cancer activity [1, 2], unveiled the study of organic compounds from then on, looking for high efficiency, low toxicity of organic germanium drugs.

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Sodium 3 - nitrobenzenesulfonate USES and production methods

Chemical properties: Sodium 3 - nitrobenzenesulfonate is white crystal. Soluble in water and ethanol.

Purpose: 1 was used as a catalyst, also used in organic synthesis, dye industry, etc. 2 this product is mild oxidant in fabric printing or pad dyeing steaming, can protect color, the fabric with scouring and mercerizing, to check the knife attached cover silk, pulp, can be offset reduction material, also can make dye synthesis of antioxidant. 3 the goods as reserving agent for VAT dyes, sulphur dyes and dye colour protective agent, rust remover and electroplating nickel back agent of the vessel, and dye intermediates and vanillin. 4 is the dye intermediates, as reserving agent for VAT dyes, sulphur dyes and dye colour protective agent, and can be used as a corrosion inhibitor and electroplating nickel back of the ship agent

Production methods: 1 industrial production can be made of nitrobenzene sulfonated and neutralization. Raw material consumption quota: benzene (98%) of 400 kg/t, sulfuric acid, nitric acid (98%) of 550 kg/t (98%) of 390 kg/t, liquid alkali (30%) of 500 kg/t, fuming sulfuric acid (including SO320 %) 410 kg / 550 kg/t t, lime, soda ash (95%), 30 kg/t. 2 in enamel kettle, to join the first 350 fuming sulfuric acid, control kettle temperature 0 ~ 5 ℃, under stirring slowly adding nitrobenzene, and keep within 1 h after 132 nitrobenzene kettle temperature to 100 ℃, heat preservation 2 h. Sulfonated sampling test the finish (1 ~ 2 material drops into 10 ml of the test tube containing water, no turbid prove to the finish line). After completion of sulfonation reaction, cooling, slowly in ice water, and in about 3 h add 2 000 salt, hours after salting out, quiet place for the night, suction, pressure dry, intermediate between nitrobenzene sulfonic acid.

Will be between nitrobenzene sulfonic acid into 500 copies of hot water, boil to dissolve. To remove a small amount of sulfone. 50 for soda ash and then add active carbon decoloring, hot filtration, the filtrate cooling crystallization. Filter cake with a small amount of water, under 50 ℃ dry, quick finished product.

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Spironolactone adapt to what are the symptoms?

1. Edema disease with other share, diuretic treatment congestive edema, liver cirrhosis ascites, renal edema, such as edema disease, its aim is to correct the above diseases with increase in the number of secondary aldosterone secretion, and against other diuretic row of potassium. Also used in the treatment of idiopathic edema.

2. High blood pressure effect for auxiliary drug for the treatment of high blood pressure.

3. Primary aldosteronism can be used for the diagnosis and treatment of the disease.

4. Prevention of hypokalemia and thiazide diuretic combination, enhance diuresis effect and prevention of hypokalemia.

Spironolactone in clinically for the treatment of intractable edema associated with elevated aldosterone, therefore is more effective for cirrhosis and nephrotic syndrome patients, and for congestive heart failure unless caused by lack of sodium secondary aldosterone in patients, the effects are poor.

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Mucuna pruriens profile

Mucuna pruriens for annual twining vine. Branches slightly was carried out in thin pilose. Pinnate 3 lobules; Lobules of 6 to 15 cm long or too, 4.5 to 10 cm wide, length, there is little more than half the width of the apical lobule clearly smaller than lateral leaflets, ovoid or elliptical long ovate, base rhombic, apex with a fine point, lateral leaflets extremely skewed, obliquely ovate to lanceolate oval, apex with a fine point, base shallow heart or nearly cross-sectional shape, both sides were white thin thin hairs; Lateral veins usually 5 per side, nearly opposite, raised; Small stipule linear, 4-5 mm long; Petiole 4 -- 9 mm, densely covered with bristles. Raceme prolapse, 12-30 cm long, has more than 10-20 flowers; Bracts small, linear lanceolate; Calyx broadly bell-shaped, densely covered with grayish white pilose and hydrophobic sting, the upper lobes is extremely rich, the lower one middle lobes linear lanceolate, ca. 8 mm long; Corolla purple or white, often shorter, flag 1.6 1.8 cm long, wing disc 2-3.5 cm long, keel 2.8 3.5 (4) cm long. Pods 8-12 cm long, 18 to 20 mm wide, soft fruit, green, densely gray or light brown hair, mature a little flat, black, uplift longitudinal rib 1-2; Seeds 6-8, oblong-elliptic, about 1.5 cm long, ca. 1 cm wide, 5-6 mm thick, gray, yellowish brown, shallow orange or black, sometimes with stripes or spots, hilum ca. 7 mm long, pale yellow white. In October flowering, fruiting in November.

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The first Androstenone in mammals

Androstenone (5α-androst-16-en-3-one) is a steroid begin in both macho and changeable diaphoresis and urine. It is aswell begin in boar's saliva, and in celery cytoplasm. Androstenone was the aboriginal beastly pheromone to be identified. It is begin in top concentrations in the saliva of macho pigs, and, if sniffed by a changeable pig that is in heat, after-effects in the changeable bold the alliance stance. Androstenone is the alive additive in 'Boarmate', a bartering artefact fabricated by DuPont awash to pig farmers to analysis sows for timing of bogus insemination.
There are two altered genotypes that acquiesce an alone to that appears to that appears to smell androstenone. The aboriginal genotype, which consists of two absolutely anatomic copies of the gene, is the RT/RT allele, and the additional is the RT/WM allele. The OR7D4 receptor has two non-synonymous individual nucleotide polymorphisms, which could could cause the gene to accept two amino acerbic substitutions, which in about-face could could cause the receptor to act differently. Those in control of the two able genes, (RT/RT) for OR7D4 tend to call the odor for the steroid as the odor of dried urine. Those with alone one gene (RT/WM) about declared the odor as anemic or were not able to ascertain it. They can aswell acquisition the that appears to that appears to smell 'pleasant', 'sweet' or 'similar to vanilla'.


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From:Natural herbal extracts

What is ZZ2?

ZZ2 Natuurboerdery means:
long appellation advance and stabilisation of the soil
optimum and acceptable yields
nutrient-dense fruit
promotion of animal health
practises consistent in an ecological balance
conservation of accustomed resources


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From:Natural herbal extracts

What is Lactose monohydrate?

Lactose is a disaccharide, molecular formula is C12H22O11, is in the mammalian milk disaccharides, hence the name. Its molecular structure is composed of a molecule of glucose and galactose condensation to form a molecule. Tiny sweet taste. Lactose is a kind of disaccharides, English name is Lactose; By a molecular beta - D - galactose and an alpha - D - glucose in beta 1, 4 - a glycosidic bond. Molecular formula C12H22O11 and molecular weight of 342.3 grams. There are two types of end group isomer: alpha and beta lactose lactose, in water solution can be transformed each other. Alpha lactose easily combined with a molecular crystal water.

Sweetness is about one 6 of the sucrose, the solid components in 2-8% lactose in milk. Young mammals gut can secrete lactase lactose as monosaccharides. Adult animals, including in addition to the Caucasian race most of the human body the activity of the enzyme lactase is reduced greatly. Therefore, drinking milk can produce symptoms such as diarrhea, abdominal distension, called lactose intolerance.

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Information about Anti-factor V（Vcoagulation factor）

Factor V (pronounced agency five) is a protein of the agglomeration system, rarely referred to as proaccelerin or labile factor. In adverse to a lot of added agglomeration factors, it is not enzymatically alive but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most conspicuously agency V Leiden) activate for thrombosis.
Genetics:The gene for agency V is amid on the aboriginal chromosome (1q23). It is genomically accompanying to the ancestors of multicopper oxidases, and is akin to agglomeration agency VIII. The gene spans 70 kb, consists of 25 exons, and the consistent protein has a about atomic accumulation of about 330kDa.

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From:Elisa test kits

Sodium Dichloroacetate can as a cancer treatment drug

Researchers in Canada, according to a latest research for many years for the treatment of metabolic disorder of cheap drugs Sodium Dichloroacetate can kill many kinds of cancer cells. Researchers at the university of alberta, Canada with the drug on the in vitro cultured human body all kinds of cells were tested, found that it can kill lung cancer, breast cancer and brain cancer cells, but no damage to healthy cells. The researchers on mice experiment also confirmed this conclusion. The researchers injected mice with cancer cells, prompting them to grow inside tumors, and a few weeks to feed them to join dichloroacetic acid salt water, the results showed that mice in vivo tumor significantly narrowed. For some patients, the researchers said Sodium Dichloroacetate may cause pain, numbness, and other issues, but if it has effect on treatment of many cancers, the cost of taking the drug is probably worth it.

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From:pharmaceutical chemicals

Information of Oxymetholone

Oxymetholone, marketed as Anadrol and Anapolon, is a constructed anabolic steroid developed in 1960 by Zoltan 'Anadrol Z' F.Its primary analytic applications cover analysis of osteoporosis and anaemia, as able-bodied as aesthetic beef advance in angular or arrested patients. The biologic was accustomed for animal use by the FDA. Later, non-steroidal drugs such as epoetin alfa were developed and accurate to be added able as a analysis for anaemia and osteoporosis after the ancillary furnishings of oxymetholone. The biologic remained accessible admitting this and eventually begin a new use in alleviative HIV crumbling syndrome. Presented a lot of frequently as a 50 mg tablet, oxymetholone is one of the arch androgenic steroids available. Similarly, there is a accident of ancillary effects.Despite actual low bounden affection with the androgen receptor, oxymetholone is awful able in announcement all-encompassing assets in physique mass, mostly by abundantly convalescent protein synthesis. For this reason, it is generally acclimated by bodybuilders and athletes. Many athletes aswell use oxymetholone as a adjustment of aegis for the joints beneath abundant loads. Oxymetholone is broadly advised by bodybuilders to accept the arch anabolic aftereffect out of all articulate steroids available.

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From:Natural herbal extracts

The preparation of Platinum

Enrichment: re-election enrichment of platinum mineral is the main method. Platinum ore of relative density is bigger, use the chute, jig, shaking table and the enrichment of air cleaning can be effectively. Natural natural gold, platinum and surface wettability is small, with xanthate flotation collector. Get concentrate after enrichment.

Refining: traditional refining methods to dissolve, reduction, precipitation and calcine. Platinum ore concentrate dissolved in aqua regia, platinum, palladium and gold in solution, with ferrous sulfate reduction from the solution of gold, then through electrolysis can be of pure gold. To join in solution of ammonium chloride, the platinum with chloroplatinic acid precipitation, ammonium by calcining crude platinum, refined by sodium bromate hydrolysis method. Dissolution and precipitation of traditional processing long and complex, incomplete separation of metal, it is hard to get high purity products. Low metal recovery rate and high cost. In 1970, began to appear in the extraction process, with the mixture of cl2 / HCl medium, the nationalisation of the precious metal leaching, improved separation efficiency and shortened the processing time, ensure to obtain high purity products. So, the modernization of platinum refining processes are based on the solvent extraction.

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From:Chemical Reagent

The basic information of the 4-bromophenylboronic acid

Toxicology: acute toxicity data: rat vein LD50:180 mg/kg, is not reported in the description of the toxic effects, in addition to other lethal dose values.

Ecology: the material may have harm to the environment, the water should be given special attention.

Stability: stable under atmospheric pressure.

Storage: 0-6 ℃, avoid light, a cool and dry place, sealed storage.

CAS no. : 5467-74-3

English name: 4 - Bromophenylboronic acid

English synonyms: AKOS BRN - 0005; RARECHEM AH PB 0075; 4 - Bromophenylboronic; P - bromophenylboricacid; 4 - bromophenylboric acid; 4 - BROMOPHENYLBORONIC ACID; P - BROMOPHENYLBORONIC ACID; P - bromo - benzeneboronicaci; (4 - Bromophenyl) boranediol; 4 - Bromophenylboranic acid

Chinese name: 4 - bromobenzene boric acid

Chinese synonyms: bromobenzene boric acid; Bromobenzene boric acid; Of bromine benzene boric acid; The bromine phenyl boric acid; 4 - bromobenzene boric acid; 4 - bromine phenyl boric acid; 4 - bromobenzene boric acid, 97 + %; On the base of benzene boric acid & 4 - bromobenzene boric acid; 4 - bromobenzene boric acid (contains any number of anhydride)

CBNumber: CB3361760

Molecular formula: C6H6BBrO2

Molecular weight: 200.83

MOL File: 5467-74-3. MOL

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Information of ASD ELISA Kit

Androstenedione (ASD) are extracted from testis or urine a steroid with androgen effect of compound. Used as a medicine intermediates of steroid hormones.

Use: simplified hormone drugs, testis or urine from a steroid with androgen effect of compound, testosterone propionate norethindrone, intermediates, are widely used rheumatoid arthritis, contraception, diuresis and all sorts of infectious inflammation control, etc., from 17 alpha hydroxyprogesterone formed by the role of C17 - C20 cracking enzyme C19 steroid compounds, as intermediates in the 17th beta hydroxy steroid dehydrogenase generated under the action of testosterone. This compound is about 1/10 of the male hormone testosterone.

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Information about Anti-ODC（Ornithine decarboxylase）

The agitator ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine (a artefact of the urea cycle) to anatomy putrescine. This acknowledgment is the committed footfall in polyamine synthesis. In humans, this protein has 461 amino acids and forms a homodimer.
The ornithine decarboxylation acknowledgment catalyzed by ornithine decarboxylase is the aboriginal and committed footfall in the amalgam of polyamines, decidedly putrescine, spermidine and spermine. Polyamines are important for stabilizing DNA structure, the DNA bifold strand-break adjustment alleyway and as antioxidants. Therefore ornithine decarboxylase is an capital agitator for corpuscle growth, bearing the polyamines all-important to balance anew actinic DNA. Lack of ODC causes corpuscle apoptosis in beginning mice, induced by DNA damage.

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From:Elisa assay kits

Information about 1-(2'-hydroxylethyl)-3-methylimidazolium tetrafluoroborate

Molecular dynamics simulations of a 5 nm-thick band of the ionic aqueous 1-(2'-hydroxylethyl)-3-methylimidazolium tetrafluoroborate, [(OH)C2C1im][BF4], over silica, alumina and boro-silicate bottle substrates accept been performed. The anatomy of the ionic aqueous at the solid-liquid interface has been interpreted demography into annual the agnate accustomed body profiles, crabbed interfacial structure, orientational acclimation and collapsed body contours. Comparisons with beginning abstracts advance that the adsorption and stratification action of ionic liquids over solid substrates can be accurately modeled application a astute arrangement of a non-uniform baggy substrate such as a bottle material.

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From:Catalyst chemistry

What is Rapamycin/Sirolimus?

Sirolimus (INN/USAN), aswell accepted as rapamycin, is an immunosuppressant biologic acclimated to anticipate bounce in agency transplantation; it is abnormally advantageous in branch transplants. It prevents activation of T beef and B beef by inhibiting their acknowledgment to interleukin-2 (IL-2). Sirolimus is aswell acclimated as a coronary stent coating. Sirolimus works, in part, by eliminating old and aberrant white claret cells.[citation needed] Sirolimus is able in mice with autoimmunity and in accouchement with a attenuate action alleged autoimmune lymphoproliferative affection (ALPS).
A macrolide, sirolimus was apparent by Brazilian advisers as a artefact of the bacillus Streptomyces hygroscopicus in a clay sample from Easter Island— an island aswell accepted as Rapa Nui. It was accustomed by the FDA in September 1999 and is marketed beneath the barter name Rapamune by Pfizer (formerly by Wyeth).
Sirolimus was originally developed as an antifungal agent. However, this use was alone if it was apparent to accept almighty immunosuppressive and antiproliferative properties. It has back been apparent to prolong the activity of mice and ability aswell be advantageous in the analysis of assertive cancers.


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From:Lactic acid bacteria

The basic information of the Bromomethylcyclopentane

CAS no. : 3814-30-0

English name: Bromomethylcyclopentane

English synonyms: Bromomethyl cyclopentane; Bromomethylcyclopentane [(Bromomethyl) cyclopentane]

Chinese name: bromine methyl cyclopentane

English synonyms: bromine methyl pentane; Bromine methyl cyclopentane; Cyclopentyl bromine (methyl)

CBNumber: CB4971810

Molecular formula: C6H11Br

Molecular weight: 163.06

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From:pharmaceutical chemicals

Ammonia (SCR) NOx reduction of choice Catalysts RN-302 some of the effects

Selective catalytic reduction (Selective Catalytic Reduction, SCR) is the principle of the catalyst, a reducing agent under the NH3 290-400 ℃ reduction of NO and NO2 N2, NH3 hardly occurs while the oxidation reaction, thereby increasing the N2 selectivity, reduced consumption of NH3.
System is the SCR catalytic reaction process is the core, with the NH3 purge nozzles and fly ash, flue gas along the catalyst loaded into the SCR reactor, the catalyst surface of the catalytic reduction of NH3 to N2. The SCR catalyst is a key system, the design and selection of the catalyst is determined by the flue gas conditions, the component to determine, influence the design of the three interacting factors removal rate of NOx, NH3 escape rate and volume of catalyst. 2013 is commonly used in commercial vanadium catalyst, such as V2O5/TiO2 and V2O5-WO3/TiO2. Mainly in the form of plate, honeycomb and corrugated plate three. The process in the late 1970s, developed first in Japan, 80 years later, Europe and the United States have been put into industrial applications. In a molar ratio of NH3/NOx is 1, NOx removal rate of 90%, NH3 control the amount of escaping 5 mg / L or less.
As the technology matures and the high denitrification rate, SCR method is now in the world into a large industrial boiler flue gas denitrification mainstream technology. As of the end of 2010, China has put into operation the flue gas denitration unit capacity of more than 200 million kW, accounting for about 28% of the capacity of coal-fired generating units, which accounted for 95% of the SCR unit.
Diesel particulates generated (PM) and nitrogen oxide (NOx) emissions in the two most contaminants. From 2013 to reduce vehicle exhaust emissions technology pathways of view, to reach Euro Ⅳ emission standards, generally no longer from the structural aspects of the engine itself measures are often taken in the exhaust aftertreatment way to reduce pollutant emissions, while Urea-SCR Selective Catalytic Reduction is the most realistic approach, which can reduce NOx in the engine exhaust more than 50%.


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From:Catalyst chemistry

GABAA Receptor δ subunit (N-Term) Polyclonal Antibody Information

The N-terminus(N-Term) (also accepted as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) refers to the alpha of a protein or polypeptide concluded by an amino acerbic with a chargeless amine accumulation (-NH2). The assemblage for autograph peptide sequences is to put the N-terminus on the larboard and address the arrangement from N- to C-terminus. When the protein is translated from agent RNA, it is created from N-terminus to C-terminus.

Chemistry
Each amino acerbic has a carboxyl accumulation and an amine group, and amino acids hotlink to one addition to anatomy a alternation by a aridity acknowledgment by abutting the carboxyl accumulation of one amino acerbic to the amine accumulation of the next. Thus, polypeptide chains accept an end with an absolved carboxyl group, the C-terminus, and an end with an amine group, the N-terminus.
When the protein is translated from agent RNA, it is created from N-terminus to C-terminus. The amino end of an amino acerbic (on a answerable tRNA) during the addendum date of translation, attaches to the carboxyl end of the growing or beginning chain. Since the alpha codon of the abiogenetic cipher codes for the amino acerbic methionine, a lot of protein sequences alpha with a methionine (or, in bacteria, mitochondria and chloroplasts, the adapted adaptation N-formylmethionine, fMet). However, some proteins are adapted posttranslationally, for archetype by break from a protein precursor, and accordingly may accept altered amino acids at their N-terminus.


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From:Raw pharmaceutical materials

TYROTHRICINE discovery

Dubos (R.J.Dubos, 1939) was added to the soil at 37 ℃ for staphylococcal seen when added staphylococci were dissolved. He was isolated from a soil fungus spores and culture fluid from its precipitation in pH3-4.6 will inhibit the growth of Gram-positive bacteria isolated as a crystal substance named TYROTHRICINE, taken together with the study of penicillin the first step in the study antimicrobial substances. Was divided into tyrothricin from acetone - ether mixture extracted gramicidin (gramicidin) and their residues in casein peptides retained Brevibacterium (tyrocidine).

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From:Natural herbal extracts

Wortmannin related research

PI3K/Akt inhibitor wortmannin research on leukemia cell proliferation and apoptosis , and to explore its possible mechanism . Methods: The effect of different concentrations of wortmannin in human myeloid leukemia cell K562, using the MTT cell proliferation , single cell gel electrophoresis to detect DNA damage formation of the " comet "-like smearing , AnnexinV-FITC / PI double staining to detect apoptosis , Westernblotting, RT-PCR detection of K562 cells after wortmannin total Akt and phosphorylated Akt and NF-κB gene and protein expression level changes . Results : wortmannin in a time - inhibited dose-dependent manner the proliferation of K562 cells , the IC50 value of 24h 25nmol / L. Wortmannin -induced apoptosis of K562 cells , and its role in a dose -dependent enhancement . Wortmannin in K562 cell DNA strand breaks , presenting " comet " tail phenomenon, its tail length and tail were significantly higher (P0.01). Wortmannin can be both protein and gene level in a dose- dependent manner and inhibited phosphorylation of NF-κB expression of Akt , total Akt protein but not significantly affected. Conclusion: wortmannin time- and dose- dependent manner inhibited the proliferation of K562 cells and induce apoptosis , which may relate to reduced phosphorylation of PI3K/Akt signaling pathway and NF-κB protein expression.


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From:Best Probiotics

Hydnocarpic acid-related information

Flacourtiaceae woody plants, leaf, leaves alternate, rarely opposite or whorled (China no); stipules small. Flowers small, actinomorphic, unisexual or bisexual, usually dioecious or hybrid strains; inflorescence racemose corymbs, panicles, clusters of inflorescence, etc., usually 2 to 7 calyx, petals deposit or absent; Tori usually with glands, stamens usually numerous, scarce number of anthers 2-celled, ovary superior, upper half, rarely inferior, 1 to 2 rooms, parietal placentation, ovules anatropous. The fruit is a capsule, berry, drupe (China without). Seed aril, a few winged, endosperm, cotyledon large. Slightly fragrant flowers, the nectary, is insect-pollinated plants, pregnancy rate, the results are more. Pollen roughly nearly spherical, nearly prolate to prolate. Size (12 ~ 36.6) × (8 ~ 40) microns. With 2 to 3 or 3 colporate intended colporate, bore horizontal length, contour explicitly or implicitly, how thick the outer to the inner wall. Finely reticulate surface. Chromosome number x = 10,11,12.
Economic Value:
Flacourtiaceae versatile plants, medicinal plants Hydnocarpus genus, genus horse egg fruit, oak genus, etc., several Hydnocarpus and horse egg fruit Hydnocarpus oleic acid (Chaulmoogric acid, C18H32O2) and sub-oleic Hydnocarpus (Hydnocarpic acid, C16H28O2) for the treatment of leprosy; Hill peel the genus Jatropha oil yield 32.82%, 28.43% oil content seeds, edible oils and treated for light industrial use; Sri Lanka day feeding wood (female students) is tall trees, fine-grained, solid material for a variety of timber, is also a fine tropical tree species; snuffbox trees, large spiny wooden fruit edible fruit; Philippine oak, white background red wood sub endangered; horse egg fruit, Hainan Hydnocarpus hairless day material wood as national key protected plants, white-backed red sub-wood, pearl thorn Hiiragi, Hainan day feeding wood, Guangxi day feeding wood, Quang Nam-day feeding wood, were pulse-day feeding wood, short calyx day feeding wood, wide petal day feeding wood, wood materials Brachystachyum day, willow day feeding wood, mountain Calligonum, goats hornbeam, Yunnan, Guizhou, goat horn tree, flower thinning oak, such as China, Yunnan blackmailed crisp endemic.

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From:Natural herbal extracts

Uvae Ursi fluid extract leaves (guyuba) effect

Protect vision, prevent blindness, improve myopia, macular degeneration, diabetic retinal disease, pigment retinal inflammation and night blindness, etc. 

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From:Natural herbal extracts

Sulphadimidine related presentations

Sulfa drugs for the broad spectrum antibacterial agents, similar in structure to para-aminobenzoic acid (PABA), PABA competitive action with the bacterial two-synthase in vivo, thereby preventing bacteria PABA synthesis required for the process of folic acid, reduced folate metabolic activity with the amount, while the latter is a bacterial purine synthesis, thymidine, and DNA (DNA) of the necessary material, thus inhibiting bacterial growth and reproduction. Sulfa drugs action can be PABA and its derivatives (procaine, tetracaine) antagonized, in addition pus and the organization of the existence of decomposition products from the antagonism, because it provides the necessary material for bacterial growth.
Sulphadimidine is an antibacterial sulfa drugs; induction of CYP3A4 expression, and by N-acetyl transferase acetylation; exhibit pharmacokinetics of dependence, by means of the male specific isoforms metabolize CYP2C11; inhibit dihydrofolate synthesis enzymes, to hinder the effect of folate synthesis. With sulfadiazine equivalent effect. For the treatment of hemolytic streptococcus, meningococcus, pneumococcus infections, lasting.
As a feed additive for the prevention of hemolytic streptococcus and staphylococcus infections, where the main treatment of fowl cholera, fowl typhoid, coccidiosis and so on.
For the control of Staphylococcus and Streptococcus infections solubility of hemolytic streptococcus and other bacteria are inhibited pleurisy bacteria, the main treatment of fowl cholera, fowl typhoid, coccidiosis, etc.
As antibacterial agents for the prevention of hemolytic streptococcus and staphylococcus infections, for the treatment of hemolytic streptococcus, meningococcus, pneumococcus infections. Primarily for the treatment of fowl cholera, fowl typhoid, coccidiosis and so on.


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From:Acridine Raw Material

Aldosterone some information

Aldosterone the nature and Stability:
1 Stability stable
2 Materials to avoid acid chlorides, acid anhydrides, strong oxidizing agents
3 Conditions to avoid heat
4 Hazardous Polymerization Will not polymerize.
5 decomposition products hydrogen bromide

Aldosterone storage methods:
Storage Precautions Store in a cool, ventilated warehouse. Keep away from fire and heat. Keep container tightly closed. Should oxidants, food chemicals stored separately and avoid mixing reservoir. Explosion-proof lighting, ventilation facilities. Prohibit the use of easy to produce sparks of mechanical equipment and tools. Storage areas should be equipped with spill response equipment and materials suitable host.

Aldosterone synthesis method:
By the o-aminophenol by diazotization, bromination derived: (a) diazotized o-aminophenol with water, stir, add concentrated sulfuric acid and ice cooling to below 5 ℃. Slowly sodium nitrite solution, the reaction temperature was maintained below 5 ℃ diazonium salts. (2) adding cuprous bromide bromide hydrobromide was dissolved with stirring heavier diazonium salt, the addition was complete stirring 0.5h, placement, steam distillation to a distillate oil tilting up, standing separation of the oil, the oil vacuum distillation derived.

Aldosterone uses:
1. The manufacture of disinfectants used in organic synthesis, drug intermediates, solvents.
2  used in organic synthesis.




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From:Hormonehome

Testosterone propionate introduce the function, etc.

Function of the role: Testosterone propionate role with testosterone, methyltestosterone same, but the duration of action than intramuscular lasting injections every 2 to 3 days once. Clinically applicable testis syndrome, cryptorchidism, male hypogonadism; gynecological diseases menorrhalgia, uterine fibroids; senile osteoporosis and aplastic anemia. By stimulating the kidneys secrete erythropoietin role or have a direct stimulating effect on the bone marrow. Primary testicular hypofunction androgen replacement therapy; genital dysplasia.
Large doses can cause virilization, edema, liver damage, jaundice, and dizziness. Allergic reactions should be discontinued. Liver and kidney dysfunction, prostate cancer patients and pregnant women hanged. If crystals have formed injection, can be heated dissolved injections. Delayed puberty and dwarfism; variety of chronic wasting disease.

Characterized as: the goods in the body first converted to 5α dihydrotestosterone (5α-dihyrotesterone), later with cell receptors, into the nucleus, chromatin function, activation of RNA polymerase, promote protein synthesis and cell metabolism. In addition, testosterone propionate by erythropoietin stimulate red blood cell formation and differentiation. Although this product can be absorbed orally, but will quickly destroy the liver and failure, it is generally used intramuscular injection. After intramuscular injection of testosterone propionate, slow absorption, and its delay onset time 2-4 days. In the blood, 98% of testosterone and sex hormone binding globulin, only 2% of free form. Half-life of 10-20 minutes. Testosterone inactivated in the liver, metabolites androsterone and DHEA original bile alkyl ketones. 90% of them with glucuronic acid and sulfuric acid combined form from the urine. Approximately 6% of the product is non-binding form by the bile, which can still be a small part of resorption, formation of enterohepatic circulation.

Adverse reactions :17-α alkyl substituted testosterone has some toxicity to the liver and can cause jaundice. Long been used in female patients may cause acne, hirsutism, deepening voice, changes in libido and other masculine performance. When they find liver dysfunction and female masculine performance, should be discontinued immediately. Large doses can cause virilization, edema, liver damage, jaundice, and dizziness.
Allergic reactions should be discontinued. Liver and kidney dysfunction, prostate cancer and pregnant women hanged. If crystals have formed injection, can be heated dissolved injections. Pregnant and lactating women, prostate cancer patients with disabling; medication should regularly check liver function, liver damage if you should reduce the dosage or disabled; prepubescent children should be applied in reduction, and every 6 months bone age measured 1 .


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Nandrolone decanoate (Deca-Durabolin) Some notes

Nandrolone decanoate (Deca-Durabolin) is white or milky white or light yellow crystal at the end, no foul. Mainly used for protein deficiency, such as chronic wasting disease, premature children, malnutrition, weight loss after surgery frail, loss of appetite, chronic diarrhea, but also for difficult to heal fractures, osteoporosis.
Note:
1, liver, kidney, heart dysfunction careful.
2. Prostatic hyperplasia, prostate cancer, high cholesterol, hypertension patients and pregnant women, disabled.
3. At below 10 ℃ shading confined preservation.
Other Considerations with Nandrolone.
4. Long-term heavy use of the product can cause sodium retention, liver damage, slightly masculine women and so on.


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Ethinyl Estradiol indications

Ethinyl estradiol is 3 - hydroxy-19 - demethyl-17α-pregna-1, 3,5 (10) - triene-20 - alkynyl -17 - ol. Calculated on dry goods, including C20H24O2 should be 97.0% ~ 103.0%. White or almost white crystalline powder; odorless. This product is ethanol, propanol or ether soluble, dissolved in chloroform, insoluble in water. The product of the melting point (Appendix Ⅵ C) to 180 ~ 186 ℃.
Indications:
⒈ estrogen deficiency, treatment of female gonadal dysfunction, amenorrhea, menopausal syndrome, etc.; for advanced breast cancer (postmenopausal women), the treatment of advanced prostate cancer; drugs in combination with progesterone, can inhibit ovulation, can be used for contraceptives. The main clinical medicine as inhibiting ovulation; also used in pediatric cryptorchidism and androgen excess, pituitary tumors. For the diagnosis of hypothalamic - pituitary - gonadal dysfunction, according to which changes in gonadotropin and sex hormone levels.
⒉ treatment due to inadequate secretion of gonadotropin hypogonadism amenorrhea and infertility, infertility multiple ovarian follicles. Amenorrhea associated with weight loss, should be corrected with diet weight. Also used for prostate cancer (often with cyproterone or fluorine carboximide combined), delayed puberty or early and endometrial bit different. Mainly used in suppressing ovulation to achieve the purpose of contraception.



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