Aldosterone some information

Aldosterone the nature and Stability:
1 Stability stable
2 Materials to avoid acid chlorides, acid anhydrides, strong oxidizing agents
3 Conditions to avoid heat
4 Hazardous Polymerization Will not polymerize.
5 decomposition products hydrogen bromide

Aldosterone storage methods:
Storage Precautions Store in a cool, ventilated warehouse. Keep away from fire and heat. Keep container tightly closed. Should oxidants, food chemicals stored separately and avoid mixing reservoir. Explosion-proof lighting, ventilation facilities. Prohibit the use of easy to produce sparks of mechanical equipment and tools. Storage areas should be equipped with spill response equipment and materials suitable host.

Aldosterone synthesis method:
By the o-aminophenol by diazotization, bromination derived: (a) diazotized o-aminophenol with water, stir, add concentrated sulfuric acid and ice cooling to below 5 ℃. Slowly sodium nitrite solution, the reaction temperature was maintained below 5 ℃ diazonium salts. (2) adding cuprous bromide bromide hydrobromide was dissolved with stirring heavier diazonium salt, the addition was complete stirring 0.5h, placement, steam distillation to a distillate oil tilting up, standing separation of the oil, the oil vacuum distillation derived.

Aldosterone uses:
1. The manufacture of disinfectants used in organic synthesis, drug intermediates, solvents.
2  used in organic synthesis.




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Testosterone propionate introduce the function, etc.

Function of the role: Testosterone propionate role with testosterone, methyltestosterone same, but the duration of action than intramuscular lasting injections every 2 to 3 days once. Clinically applicable testis syndrome, cryptorchidism, male hypogonadism; gynecological diseases menorrhalgia, uterine fibroids; senile osteoporosis and aplastic anemia. By stimulating the kidneys secrete erythropoietin role or have a direct stimulating effect on the bone marrow. Primary testicular hypofunction androgen replacement therapy; genital dysplasia.
Large doses can cause virilization, edema, liver damage, jaundice, and dizziness. Allergic reactions should be discontinued. Liver and kidney dysfunction, prostate cancer patients and pregnant women hanged. If crystals have formed injection, can be heated dissolved injections. Delayed puberty and dwarfism; variety of chronic wasting disease.

Characterized as: the goods in the body first converted to 5α dihydrotestosterone (5α-dihyrotesterone), later with cell receptors, into the nucleus, chromatin function, activation of RNA polymerase, promote protein synthesis and cell metabolism. In addition, testosterone propionate by erythropoietin stimulate red blood cell formation and differentiation. Although this product can be absorbed orally, but will quickly destroy the liver and failure, it is generally used intramuscular injection. After intramuscular injection of testosterone propionate, slow absorption, and its delay onset time 2-4 days. In the blood, 98% of testosterone and sex hormone binding globulin, only 2% of free form. Half-life of 10-20 minutes. Testosterone inactivated in the liver, metabolites androsterone and DHEA original bile alkyl ketones. 90% of them with glucuronic acid and sulfuric acid combined form from the urine. Approximately 6% of the product is non-binding form by the bile, which can still be a small part of resorption, formation of enterohepatic circulation.

Adverse reactions :17-α alkyl substituted testosterone has some toxicity to the liver and can cause jaundice. Long been used in female patients may cause acne, hirsutism, deepening voice, changes in libido and other masculine performance. When they find liver dysfunction and female masculine performance, should be discontinued immediately. Large doses can cause virilization, edema, liver damage, jaundice, and dizziness.
Allergic reactions should be discontinued. Liver and kidney dysfunction, prostate cancer and pregnant women hanged. If crystals have formed injection, can be heated dissolved injections. Pregnant and lactating women, prostate cancer patients with disabling; medication should regularly check liver function, liver damage if you should reduce the dosage or disabled; prepubescent children should be applied in reduction, and every 6 months bone age measured 1 .


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Nandrolone decanoate (Deca-Durabolin) Some notes

Nandrolone decanoate (Deca-Durabolin) is white or milky white or light yellow crystal at the end, no foul. Mainly used for protein deficiency, such as chronic wasting disease, premature children, malnutrition, weight loss after surgery frail, loss of appetite, chronic diarrhea, but also for difficult to heal fractures, osteoporosis.
Note:
1, liver, kidney, heart dysfunction careful.
2. Prostatic hyperplasia, prostate cancer, high cholesterol, hypertension patients and pregnant women, disabled.
3. At below 10 ℃ shading confined preservation.
Other Considerations with Nandrolone.
4. Long-term heavy use of the product can cause sodium retention, liver damage, slightly masculine women and so on.


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Ethinyl Estradiol indications

Ethinyl estradiol is 3 - hydroxy-19 - demethyl-17α-pregna-1, 3,5 (10) - triene-20 - alkynyl -17 - ol. Calculated on dry goods, including C20H24O2 should be 97.0% ~ 103.0%. White or almost white crystalline powder; odorless. This product is ethanol, propanol or ether soluble, dissolved in chloroform, insoluble in water. The product of the melting point (Appendix Ⅵ C) to 180 ~ 186 ℃.
Indications:
⒈ estrogen deficiency, treatment of female gonadal dysfunction, amenorrhea, menopausal syndrome, etc.; for advanced breast cancer (postmenopausal women), the treatment of advanced prostate cancer; drugs in combination with progesterone, can inhibit ovulation, can be used for contraceptives. The main clinical medicine as inhibiting ovulation; also used in pediatric cryptorchidism and androgen excess, pituitary tumors. For the diagnosis of hypothalamic - pituitary - gonadal dysfunction, according to which changes in gonadotropin and sex hormone levels.
⒉ treatment due to inadequate secretion of gonadotropin hypogonadism amenorrhea and infertility, infertility multiple ovarian follicles. Amenorrhea associated with weight loss, should be corrected with diet weight. Also used for prostate cancer (often with cyproterone or fluorine carboximide combined), delayed puberty or early and endometrial bit different. Mainly used in suppressing ovulation to achieve the purpose of contraception.



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Gestodene use and interaction

Gestodene purposes: as anti-progesterone drug
Pharmacology and Applications: To date, the strongest effect of progesterone and a minimum dose contraceptives. Its progestin norethindrone activity of L-A 2 times, no androgen and estrogen activity, there are anti-estrogen effect. Rapidly and completely absorbed orally, after 1 to 2 hours peak blood concentration, bioavailability 100 percent, eliminating t1/28 hours. Composite sheet consisting of clinical and ethinyl estradiol or three photos as short-acting oral contraceptives. Due to its contraceptive effect is reliable, cycle control, and on the favorable impact on lipid metabolism can improve hdl, so for the most ideal kind of oral contraceptives.

Interactions:
1, can be elevated plasma concentration of the drug Gestodene: eg atorvastatin, vitamin C and other drug metabolizing enzyme preparations such as fluconazole. Triacetyl oleandomycin used simultaneously with combined oral contraceptives may increase the incidence of intrahepatic cholestasis of risk.
2, can Gestodene contraceptive effect lowering drugs; antimicrobial agents, especially broad-spectrum antibiotics, drug metabolizing enzyme inducers such as rifampicin, phenobarbital, phenytoin, etc., should be avoided while taking.
3, Gestodene affect the efficacy of other drugs, it has weakened the role of anti-hypertensive drugs, anticoagulants and hypoglycemic agents; make enhanced efficacy of tricyclic antidepressants.
4, if used simultaneously with other drugs may occur drug interactions, please consult your physician or pharmacist.



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Mifepristone contraceptive efficacy

Mifepristone for the new anti-progesterone, no progesterone, estrogen, androgen and anti-estrogenic activity, with the progesterone receptor and glucocorticoid receptor binding, endometrial progesterone receptor affinity 5 times stronger than progesterone, pregnant animals for each period of pregnancy are abortion effect, can be used as non-surgical anti-pregnancy drugs. In the effective dose had no significant effect on cortisol levels. Because the drug can lead to insufficient uterine activity, anti-pregnancy when used alone incomplete abortion rate is higher, but it can increase the sensitivity of uterine prostaglandins.
Mifepristone also has a role in softening and dilatation of the cervix, it is clinically except for the anti-pregnancy, pregnancy ended after reminders, fetal death, abortion, but also for gynecological surgical procedures, such as the IUD placement and removal, take the inner membrane specimen, cervical dysplasia and cervical dilation and laser separation dilatation and curettage, The oral bioavailability of 70%. Plasma protein binding rate of 98% after 1.5 hours peak blood concentration, the role for 12 hours, eliminating the t1 / 2. Of 18 hours. Generally begin 30 hours after oral administration of vaginal bleeding, continued from 1 to 16 days. Endometrial progesterone receptor affinity five times stronger than progesterone, pregnant animals for each period of pregnancy are abortion effect, can be used as non-surgical anti-pregnancy drugs. IPPF medication is divided into two kinds of birth control pills and anti-pregnancy drug. Taking different doses of mifepristone may achieve different effects, under normal circumstances, each taking 10-25 mg of mifepristone for emergency contraception; taking 150 mg can be terminated within 49 days of pregnancy. Diagnosis of intrauterine pregnancy to the FDA. Menopause generally should not exceed 49 days, pregnancy shorter the better.


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Clinical application of Stanozolone

Stanozolone is a white crystalline powder, odorless. Almost insoluble in water, soluble in ethanol, chloroform, slightly soluble in acetone. Closed to avoid light preservation. Assimilation of this product is protein and male activity is weak, the differentiationindex of about 120. Clinical for the treatment of various relates tovascular diseases, such as Behr Chet syndrome (Behcet syn-drome), vascular phenomenon in hereditary angioedema,Raynaud's syndrome, superficial thrombophlebitis, venous ulcer.Can also be used for chronic bone wasting disease, osteoporosis,and growth hormone treatment in Turner syndrome (Turn-erssyndrome). Adverse reactions with nandrolone phenylpropionate.

Clinical application:

Female patient androgen or anabolic hormone, can cause malephenomenon, such as hirsutism, long beard, voice and tonedown, acne, generally in the withdrawal symptoms gradually subsided. Long-term application of this kind of hormones in malepatients, drug may be converted in the body to estrogen, and mayinhibit the secretion of gonadotropin and cause atrophy of testisand spermatogenesis suppression; due to the inhibition of endogenous testosterone, can lead to impotence; children's long-term application of androgen, can seriously affect the growth and development, such as accelerated epiphyseal closure effect instopping drug after still can last several months; application ofanabolic hormone, can lead to obesity. 17 effect of α - methyl testosterone on liver damage was more serious, the main interference intrahepatic bile capillary excretion function, make the cholestasis in the liver lobule central capillary bile duct damage caused by stasis of liver cells, bile, clinical manifestations of cholestatic hepatitis. Long-term use of androgens, may occur in liver cancer, prostate cancer and renal cell carcinoma. In addition, because of the sodium and water retention effect, can cause edema. Kidney disease and heart failure patients with prostate cancer are disabled, pregnant women

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