Pirenzepine pharmacological effects

Pirenzepine as a selective anticholinergic drugs, cells of the stomach variety of alkali receptors with high affinity, and for smooth muscle, cardiac muscle and salivary glands and other variety of alkali receptor affinity is low, so the application of general treatment doses, only can inhibit the secretion of gastric acid, and there are few other choline drug resistance to the pupil, gastrointestinal smooth muscle, heart, salivary glands and bladder muscle and other side effects. Doses can inhibit the production of saliva, only large doses can inhibit gastrointestinal smooth muscle and causes tachycardia.

Pirenzepine is mainly used in the treatment of gastric and duodenal ulcers, can obviously relieve patients' pain, reduce the dosage of antacids. Recent ulcer healing rate at about 70% one 94%, curative effect and cimetidine, is better than that of carbenoxolone sodium. With cimetidine share can enhance the effect of the inhibition of gastric acid secretion.

Rubitecan medical effect

Rubitecan, tonsillitis caused by clinical mainly used in streptococcus, scarlet fever, diphtheria and carrier, gonorrhea, listeria disease, streptococcus pneumoniae lower respiratory tract infection (above applies to patients is not resistant to penicillin for legionella pneumonia and mycoplasma pneumonia, this product can be used as the preferred drug application. Can be applied to the upper respiratory tract infection caused by influenza bacillus and staphylococcus aureus skin and soft tissue infection, syphilis, and intestinal amebiasis.

Warm reminder: potential hepatotoxicity, long-term and large doses can cause cholestasis and elevated liver enzymes, especially brew erythromycin caused more easily. Also can cause tinnitus, hearing loss, caused more easily injected. Other common gastrointestinal reaction, drug fever, rash, urticaria and other allergic reactions. Cardiovascular system visible ventricular arrhythmia, ventricular tachycardia, long QT, etc.

What are the role of Nizatidine

Nizatidine is a kind of sexual selection antagonist medicine, mainly used for the treatment and prevention of gastric and duodenal ulcer.

Nizatidine for H2 receptor blockers. Animal studies have shown that by the stimulation such as histamine, gastric secrete element and things caused by inhibition of gastric acid secretion than cimetidine for Ding Jiang 8.9 times its antiulcer effect than cimetidine for Ding Jiang 3 ~ 4 times, and are similar to those of ranitidine. Clinical studies have demonstrated that this product can significantly inhibit gastric acid secretion for 12 hours at night. 1 oral healthy subjects 300 mg, inhibition of gastric acid secretion at night an average of 90%, 10 hours after gastric acid secretion is still down 52%. Oral 【 75 ~ 300 mg does not affect the activity of pepsin in stomach secretions, pepsin total to reduce the secretion of gastric secretion volume reduced in proportion. Serum gastric secrete element or for basic food caused by high blood stomach gastrin-releasing little role; 12 hours after giving this product feeding, did not see the stomach secrete hormone is bounce. This product has no resistance to androgen effects. Oral this product after the absolute bioavailability of more than 90%, to 150 mg or 300 mg, Cmax is 700 ~ 1800 mu g/L and 1400 ~ 3600 mu g/L, t Max 0.5 ~ 5 hours, 12 hours after the treatment the blood drug concentration below 10 mu g/L; T1/2 beta is 1 ~ 2 hours, Vd is 0.8 ~ 1.5 L/kg, CL is 40 ~ 60 L/h, oral 150 mg AUC 314.6 (mu g h.)/ml. Due to the short half-life, clear quickly, the accumulation of individual normal renal function is generally not happen. This product more than 90% of the oral dose within 12 hours with the urine excretion, less than 6% of doses with fecal excretion, about 60% of the oral dose excreted unchanged; By renal tubular secretion and excretion, the CLr is 500 ml/min, to moderate in renal dysfunction significantly longer half-life and reduce clearance. Plasma protein conjugation rate is about 35%.

Activity of endoscopy confirmed duodenal ulcer patients, results were compared with the placebo double-blind experiments show that this product can make the ulcer healing. Taking this product 150 mg before bed can make the duodenal ulcer recurrence rate is decreased obviously.

Used in active treatment of duodenal and benign gastric ulcer, course of 8 weeks; Can also be used for duodenal ulcer healing for prevention.

What is the Fenbufen

Fenbufen is white or kind of white pieces. This product is white or white crystalline powder; Odourless; Taste sour. This product dissolved in ethanol, almost insoluble in water; Easily dissolved in a hot alkaline solution.

Fenbufen is a relatively new type of long-term non-steroidal anti-inflammatory and analgesic drug. According to animal studies, although the anti-inflammatory and analgesic action of this crystal was lower than those of indomethacin, but stronger than aspirin. Toxicity is smaller than indomethacin, gastrointestinal side effects than aspirin and other non-steroidal anti-inflammatory and analgesic drug. The pharmacological research showed that the crystal in the body metabolism into PCB ethyl ester, which inhibits the synthesis of prostaglandins, thereby blocking the role of inflammatory mediators, think this is this article main mechanism of anti-inflammatory effects. Finn cloth as a precursor of biphenyl ethyl ester, can avoid taking active metabolites directly after oral stimulation of the gastrointestinal tract. The domestic trial in rheumatoid arthritis, rheumatoid arthritis, the total effective rate was 87%. This drug is generally can make the chain of rheumatoid factor, blood sedimentation, turn back to normal or "O" and other indicators. Pathological examination did not see the main viscera have obvious pathological changes. Two hours after the oral blood concentrations of peak value. T 1/2 for 12 ~ 17 hours. Used for rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout treatment, etc. Also used for toothache, pain pain after surgery, trauma, pain, etc.

What are Ethionamide purposes

Ethionamide acetamide have bad smell, it was because of minor impurities. Has general properties of the amide. Industrial acetamide is made up of ammonium acetate on the 150 ~ 200 ℃ heating water preparation. Widely used as organic and inorganic solvents. Have a weak alkaline, can do varnish, explosives and cosmetics antacids. Also used as wetting agent of dyeing, plastic plasticizer, also for raw material manufacturing drugs and fungicides. Im Ethionamide or bromine chloride into the N - halogenated acetamide, is organic synthesis of halogenated reagents.

Ethionamide have many USES in chemical industry, plastic, dye, medicine, pesticide and other industries widely used.

What is the Lanreotide

Lanreotide, prescription drugs, synthetic growth hormone inhibin analogues, thereby inhibition on a variety of hormones, including growth hormones, thyroid stimulating hormone (TSH), insulin and glucagon.

Lanreotide is synthetic growth hormone inhibin analogues, thus inhibition on a variety of hormones, including growth hormone and thyroid stimulating hormone (TSH), insulin and glucagon. Lavaro peptides are similar to those of growth hormone inhibin, through receptors play a role. It has higher affinity foreign Zhou Shengchang inhibition receptors, similar activity, on the central nervous affinity is weak. Although the growth hormone in the body of inhibin minutes will decompose, Lanreotide attenuation period is longer, so produce a long-term role.

What is the Vitamin u

Vitamin u Chinese name: chlorinated armour sulfur amino acid, is a kind of plant extracts. Methyl chloride sulfur amino acid that is a kind of antiulcer agent, mainly used in the treatment of gastric and duodenal ulcer, it is not essential nutrients. So, strictly speaking, a sulfur amino acid chloride is not vitamin.

Found in cabbage, Chinese cabbage, cabbage, lettuce, alfalfa, and other green leafy vegetables. Can be made by reaction with methyl iodide methionine, have special smell, taste salty, bitter. Light or for a long time in the air is not stable. Soluble in water, insoluble in ethanol and aether. Acidic aqueous solution. Mainly used in the treatment of gastric and duodenal ulcer.