Information about Vinflunine tartrate

Name: Vinflunine
Chemical Synonyms: VINFLUNINE; 20 ', 20'-Difluoro-3', 4'-dihydrovinorelbine; 4'-Deoxy-20 ', 20'-difluoro-5'-norvincaleukoblastine; 4'-Deoxy-20', 20'-difluoro-8'-norvincaleukoblastine; Vinflunine Tartrate
CAS No.: 162652-95-1
Formula: C45H54F2N4O8
Molecular Weight: 816.93

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A brief introduction CD4 ELISA Kit

CD4 cells are a kind of important immune cells in the body's immune system, CD4 expression mainly in T helper (Th) cells, is Th cell TCR identify antigen for the receptor, the peptide section with MHC class Ⅱ molecules combined with, participate in Th cell antigen which is the identification of signal transduction, CD4 receptors and HIV, the AIDS virus attacks object is CD4 cells, so the test result on the immune function of patients with AIDS treatment effect of judgment, and to the important role in the judgment.

Normal adult CD4 cells per cubic millimeter in 500 to 1600, HIV infection of CD4 cells developed progressive or irregularity decline, marked the immune system is severely damaged, when CD4 cells per cubic millimeter less than 200 a, may be a variety of opportunistic infection or tumor.

Principle of HIV/AIDS infection: white blood cells are killing foreign microbe guardians of the human body, it mainly contains the CD4 and CD8 and CD4 cells play the role of "informant", CD8 cells is engulf bacteria, when AIDS virus enters the body, it will be abducted CD4 cells, CD8 cells become "the blind and the deaf", HIV invades white blood cells, then the white blood cells as their own breeding hotbed.

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What are the side effects Valporic Acid kit

A multitude of antiepileptic drugs in current valproic acid is a wide clinical application, high curative effect and safety of good choice, broad spectrum drugs. Valproic acid (DE ba jin? Not only can be used to treat various kinds of epilepsy of generalized seizures, especially the absence seizure and stiffness - clonus attack, can also be used for partial onset seizures.

Side effects: compared with carbamazepine and valproic acid has obvious tremor and weight gain effects, but less rash. The acute side effects of valproic acid, mainly (see more oral dosage forms) reaction of gastrointestinal tract and tremors. Tremor is a mild excessive performance, reduce the dose can be controlled.

Valproic acid varied chronic toxicity reaction performance. The most common is weight gain, high blood ammonia is common, but for most patients with no clinical significance. Treatment dose valproic acid will not affect cognitive function, unless you use high doses.

Atopic side effects are rare, but the risk is bigger. Thrombocytopenia associated with dose, and the severity of the surgical research shows that thrombocytopenia has nothing to do with bleeding; The incidence of pancreatitis is about 1/40 of 000; The incidence of hepatitis is about 1/10 1/40 000 ~ 000. In recent years, with the overall understanding of the risk factors, as well as the strict monitoring measures taken, did not have any reports of deaths due to pancreatitis or hepatitis.

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From:Natural herbal extracts

What is phenol?

Phenol, also known as carbolic acid, hydroxy benzene, German chemist Runge Runge (F) in 1834, found in coal tar, is one of the most simple phenols, organic matter a weak acid. Room temperature for a colorless crystals, are poisonous. Phenol is a kind of common chemicals, the production of certain resin, fungicides, preservatives and important raw material of drugs (eg, aspirin). Phenol corrosive, room temperature slightly soluble in water, soluble in organic solvents. When the temperature higher than 65 ℃, can with water in any proportion miscibility. Stick to its solution available alcohol washing on the skin, the pink phenol exposed to air.

Main application:

Important organic synthetic raw material, for making phenolic resin and bisphenol A, phenolphthalein, picric acid, salicylic acid, alkyl phenol and other chemicals, also can be used as A solvent. Widely used in the manufacture of phenolic resin, epoxy resin, polyamide fiber, plasticizer, developer, preservatives, pesticides, fungicides, dye, medicine, spices, explosive and so on.

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The introduction of the Corticosteroids ELISA Kit

Corticosteroids are made by the adrenal cortex and steroid hormone secretion, also can through the synthetic. Its pharmacological effects and complex, and widely involved in physical systems, such as the stress response, the immune response, and inflammation, carbohydrate metabolism, protein catabolism, control of electrolyte concentration in the blood.

Corticosteroids are cholesterol as raw materials synthesized in the adrenal cortex. Most of the steroid reaction must be catalyzed by cytochrome P450 enzymes. It inside the iron REDOX proteins to mitochondria as a cofactor (except 21 hydroxylase and 17 alpha hydroxylase).

The biosynthetic pathways of aldosterone and corticosterone in the first part of the same, the bottom part respectively by aldosterone synthase and 11 beta hydroxylase intermediary. These two enzymes are very similar, are able to do 11 beta hydroxy and 12 - hydroxy role, but also to 18 - oxidation. In addition, aldosterone synthase exist in the ball of the outside of the adrenal cortex; 11 beta hydroxylase are visible to zona fasciculata and zona.

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The basic information of the Vinflunine tartrate

English name: Vinflunine Tartrate

English synonyms:

CAS no. : 1201898-17-0

Molecular formula: C45H54F2N4O8 xC4H6O6

Molecular weight: 0

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The application of Bitumen

Bitumen is hydrophobic material, it impermeable, almost insoluble in water, dilute ethanol, acetone, ether, soluble in carbon disulfide, carbon tetrachloride, sodium hydroxide. Health hazard: medium toxicity. Asphalt and flue gas of skin mucous membrane irritation, has the light effect and the effect that cause cancer. China's three major asphalt toxicity: coal tar > > oil shale asphalt asphalt, before both have carcinogenicity. The main skin lesions are: asphalt light contact dermatitis, skin confined to the face, neck and other exposed parts; Melanosis, skin lesions often symmetrical distributed in the exposed parts, plate shaped, brown - deep brown - brown-black; Occupational acne; Verrucous vegetations and the accident cause thermal burns. In addition, there are dizziness, head bilges, headache, chest tightness, fatigue, nausea, loss of appetite and other systemic symptom and eye, nose, pharynx and irritation.

Application: in civil engineering, bitumen is waterproof materials and widely used anticorrosion material, mainly used in roofing, ground, underground waterproof structure, wood, steel corrosion. Or road asphalt pavement cementing materials applied widely in engineering, and it has to do with different composition of mineral materials in proportion with different structure of asphalt pavement can be built.

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The introduction of the zafirlukast

Zafirlukast, as a kind of polypeptide LTC4, LTD4 and LTE4 allergic reactions such as slow reaction substance leukotriene receptor antagonist, competitive inhibition activity of leukotriene, effectively prevent leukotriene polypeptide of the increase in vascular permeability caused by airway edema, and inhibition of leukotriene polypeptide produced by airway eosinophilia cell infiltration, reduce tracheal contraction and inflammation, relieve asthma symptoms. Drugs are highly selective and only ACTS on leukotriene receptor, does not affect the prostaglandins, thromboxane, cholinergic and histamine receptor. Good oral absorption, after about 3 h peak plasma concentration. Medication within 2 h, drug plasma concentration has yet to reach the peak can be produced in the base bronchial exercise tension first agent effect obviously. Plasma protein combined rate of 99%, urinary excretion is 10% of the oral dose, stool excretion was 89%, the elimination half-life of about 10 h. Pharmacokinetic no significant differences in the normal people and patients with renal damage. Take with food when the majority of patients (75%) of reduced bioavailability, the reduction of 40%.

In asthma pathophysiology of the disease, think leukotriene product (LT) and its receptor to produce including the effect of smooth muscle contraction, airway edema and inflammatory cells activity changes (such as acidophilic cell lung infiltrates) are associated with the signs and symptoms of asthma. Drug as an anti-inflammatory drug, can reduce the inflammatory mediators. Drugs as a strong oral peptide LTC4, LTD4 and LTE4 allergic reactions such as slow reaction substance leukotriene receptor antagonist, belong to the competitive inhibition, has the characteristics of high selectivity. In vitro studies have shown that this drug antagonism in the human body the conduction of all three leukotriene polypeptide contraction of airway smooth muscle activity (leukotriene C4, D4 and E4), and the same degree. Animal experiments showed that the effect of drugs mainly: effectively prevent leukotriene peptides due to increased vascular permeability, which can cause airway edema; Inhibition of leukotriene polypeptide produced by airway eosinophilia cell infiltration. Clinical studies also demonstrated the specificity of the drug, only on leukotriene receptor, but does not affect the prostaglandins, thromboxane and histamine and acetylcholine receptors. , according to the verified by clinical medicine with anti-inflammatory properties, 5 doses of the drug can reduce airway cells caused by antigen stimulation and non cell inflammatory substances. Placebo-controlled study found that the antigens stimulate 48 hr after bronchoalveolar lavage, zafirlukast over, inhibit acidophilic cells, lymphocytes, and the rise of tissue cells, and to reduce the alveolar macrophage stimulation produced by peroxide. Drugs can inhibit airway hyperresponsiveness antigen stimulate and platelet active factor cause bronchospasm.

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Information about Quinolinic acid

Quinolinic acid is a byproduct of the kynurenine pathway, which is amenable for catabolism of tryptophan in mammals. This alleyway is important for its assembly of the coenzyme nicotinamide adenine dinucleotide (NAD+) and produces several neuroactive intermediates including quinolinic acid, kynurenine (KYN), kynurenic acerbic (KYNA), 3-hydroxykynurenine (3-HK), and 3-hydroxyanthranilic acerbic (3-HANA).Quinolinic acid's neuroactive and excitatory backdrop are a aftereffect of NMDA receptor agonism in the brain. It aswell acts as a neurotoxin, gliotoxin, proinflammatory mediator, and pro-oxidant molecule.
Quinolinic acid is clumsy to canyon through the blood-brain barrier (BBB) and accept to be produced aural the academician microglial beef or macrophages that accept anesthetized the BBB.While  Quinolinic acid  cannot canyon the BBB, kyurenic acid, tryptophan and 3-hydroxykynurenine do and after act as precursors to the assembly of  Quinolinic acid  in the brain. The  Quinolinic acid  produced in microglia is again appear and stimulates NMDA receptors consistent in excitatory neurotoxiticity.While astrocytes are not able to aftermath  Quinolinic acid  directly, they are able of bearing KYNA, which if appear from the astrocytes can be taken in by migroglia that can in about-face access  Quinolinic acid  production.

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Information about 3-Cyano-4-methony-2-(1H)-pyridinone

English name: 4 - Methoxy - 2 - oxo - 1, 2 - dihydro - pyridine - 3 - carbonitrile

English synonyms: 4 - METHOXY - 2 - OXO - 1, 2 - DIHYDRO - 3 - PYRIDINECARBONITRILE; 4 - Methoxy - 2 - oxo - 1, 2 - dihydro - pyridine - 3 - carbonitrile; 3 - CYANO - 2 - HYDROXY - 4 - METHOXYPYRIDINE; 3-4 - methoxyl Cyano - - 2 - (1 h) - pyridione; 3 - CYANO - 4 - METHOXY - 2 - (1 h) - PYRIDINONE; 1, 2 - DIHYDRO - 4-2 - OXO - 3 - METHOXY - PYRIDINECARBONITRILE; AURORA KA - 6226. 3-4 - methoxy1 Cyano - - 2 - (1 h) - pyridione

CAS no. : 21642-98-8

Molecular formula: C7H6N2O2

Molecular weight: 150.13

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Information about teneligliptin

Dipeptidyl peptidase-4 (DPP-4) inhibitors accept afresh emerged as a new chic of antidiabetic that appearance favorable after-effects in convalescent glycemic ascendancy with a basal accident of hypoglycemia and weight gain. Teneligliptin, a atypical DPP-4 inhibitor, exhibits a different anatomy characterized by 5 afterwards rings, which aftermath a almighty and abiding effect. Teneligliptin is currently acclimated in cases assuming bereft advance in glycemic ascendancy even afterwards diet ascendancy and exercise or a aggregate of diet control, exercise, and sulfonylurea- or thiazolidine-class drugs. In adults, teneligliptin is orally administered at a dosage of 20 mg already daily, which can be added up to 40 mg per day. Because the metabolites of this biologic are alone via renal and hepatic excretion, no dosage acclimation is all-important in patients with renal impairment. The assurance contour of teneligliptin is agnate to those of added accessible DPP-4 inhibitors. However, attention needs to be acclimatized if administering teneligliptin to patients who are decumbent to QT prolongation. One abstraction has appear that the postprandial claret glucose-lowering furnishings of teneligliptin administered above-mentioned to breakfast were abiding throughout the day, and the furnishings empiric afterwards banquet were agnate to those empiric afterwards breakfast or lunch. Thus, although analytic abstracts for this new biologic are limited, this biologic shows affiance in stabilizing glycemic fluctuations throughout the day and appropriately suppressing the progression of diabetic complications. However, connected appraisal in abiding studies and analytic trials is appropriate to appraise the ability and assurance of the biologic as able-bodied as to analyze added break for its analytic use.

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Hyodeoxycholic acid is a kind of ursodeoxycholic acid

Hyodeoxycholic acid is extracted from pig bile a ursodeoxycholic acid. Can inhibit the formation of bile acid and dissolved fat, lower cholesterol and triglycerides in the blood, suitable for Ⅰ type a or b Ⅰ hyperlipidemia, sclerosis of arterial congee appearance. To bordetella pertussis, diphtheria bacillus, staphylococcus aureus, etc have certain bacteriostasis. Can be used as an anti-inflammatory drugs, the treatment of chronic bronchitis, infantile viral upper respiratory tract inflammation, etc. This product can stimulate the secretion of bile, bile is thinning and not increase the solids, applicable to biliary tract infection, cholecystitis, cholelith disease, and other non obstructive cholestasis; Can also accelerate the gallbladder contrast agent for liver and contribute to development. Can promote the intestinal fat decomposition and fat-soluble vitamins absorption, can be used in the liver and gallbladder disorders cause indigestion, can reduce cholesterol in the blood at the same time, the treatment and prevention of coronary heart disease, high blood pressure, etc

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Ciprofloxacin hydrochloride treatment of infection

Ciprofloxacin hydrochloride for prescription drugs. Used for urinary reproductive system caused by sensitive bacteria infection, including simple and complicated urinary tract infection, bacterial prostatitis, bacteria neisseria gonorrhea urethritis and cervicitis (including enzyme production strains caused by). Respiratory tract infections, including sensitive acute bronchial infection caused by gram-negative bacilli and lung infection. Gastrointestinal tract infection by shigella, salmonella, produce enterotoxin e. coli, moisture, deputy hemolytic bacterium vibrio, etc. The treatment of typhoid bone and joint infection, skin soft tissue infection, septicemia and systemic infection.

Used for 1. Caused by sensitive bacteria urinary reproductive system infection, including simple and complicated urinary tract infection, bacterial prostatitis, bacteria neisseria gonorrhea urethritis and cervicitis (including enzyme production strains caused by). 2. Respiratory tract infection, including sensitive acute bronchial infection caused by gram-negative bacilli and lung infection. 3. The gastrointestinal tract infection by shigella, salmonella, produce enterotoxin e. coli, moisture, deputy hemolytic bacterium vibrio, etc. 4. Typhoid. 5. Bone and joint infections. 6. The skin soft tissue infection. 7. Sepsis systemic infection, etc. The chemical composition  ciprofloxacin hydrochloride. Its chemical name: l - cyclopropyl - 6 - fluoro - 1, 4, 2 hydrogen. 4. Oxygen generation - 7 - (1 - piperazine) - 3 - quinoline carboxylic acid hydrochloride formula: C17H18FN3O3, HCl, and H2O.

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The classification of the Germanium Sesquioxide Organic USP

The influence of germanium on the human body is mainly can restore fatigue; To prevent anemia; Help the metabolism and so on. Many places are treated as medical auxiliary equipment. But without clinical proved to be effective. That is most will say: the body will be lighter, the pain will reduce, and so on. If taking, there have been examples of death. Clinical researchers believe that there is a dangerous thing. Will have bad effect to the kidney. But in Japan, in the jewelry industry is regarded as a health utensils in a necklace, bracelet in selling. The price does not poor.

Is divided into categories: organic germanium synthetic organic germanium, natural organic germanium, biological organic germanium three categories. Synthesis of organic germanium is half as many hydroxyethyl germanium oxide, namely, Ge - 132, screw germanium, furan germanium derivatives such as antiviral, anti-inflammatory, anti-cancer, organic germanium, is a compound of extensive pharmacological effects, but taking too much easy to cause calcium deficiency; Made of natural plant extract, natural organic germanium or eaten, to the human body without any side effects; Biological organic germanium is planted germanium compounds organisms, such as yeast, bacteria, fungus, vegetables, etc. Organic germanium compounds inhibit tumor activity possible mechanisms including enhancing immunity, scavenging free radicals and multiple aspects, such as resistance mutations. Many bioactive molecule organic germanium compounds, coordination with germanium atoms are usually oxygen, sulfur and nitrogen of high voltage negative atoms, due to their electronic absorption germanium atoms around the electron cloud of deviating from the nucleus to form a positive center. But organic germanium compounds in tumor cells and normal center can increase the potential of tumor cells, reduce its activity ability, which have the effect of restrain and kill tumor cells, which means that organic germanium compounds to inhibit the activity of tumor biological potential theory. [1]

Natural organic germanium is one of the ingredients of many medicinal plants, ginseng and other medicinal plants are rich in organic germanium, has a unique health functions. Since 1971, the Japanese scholar shallow Wells, kazuhiko synthesized by hydroxyethyl half as many germanium oxide (GeCH2COOH) 203, referred to as "Ge - 132, and proved its anti-cancer activity [1, 2], unveiled the study of organic compounds from then on, looking for high efficiency, low toxicity of organic germanium drugs.

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Sodium 3 - nitrobenzenesulfonate USES and production methods

Chemical properties: Sodium 3 - nitrobenzenesulfonate is white crystal. Soluble in water and ethanol.

Purpose: 1 was used as a catalyst, also used in organic synthesis, dye industry, etc. 2 this product is mild oxidant in fabric printing or pad dyeing steaming, can protect color, the fabric with scouring and mercerizing, to check the knife attached cover silk, pulp, can be offset reduction material, also can make dye synthesis of antioxidant. 3 the goods as reserving agent for VAT dyes, sulphur dyes and dye colour protective agent, rust remover and electroplating nickel back agent of the vessel, and dye intermediates and vanillin. 4 is the dye intermediates, as reserving agent for VAT dyes, sulphur dyes and dye colour protective agent, and can be used as a corrosion inhibitor and electroplating nickel back of the ship agent

Production methods: 1 industrial production can be made of nitrobenzene sulfonated and neutralization. Raw material consumption quota: benzene (98%) of 400 kg/t, sulfuric acid, nitric acid (98%) of 550 kg/t (98%) of 390 kg/t, liquid alkali (30%) of 500 kg/t, fuming sulfuric acid (including SO320 %) 410 kg / 550 kg/t t, lime, soda ash (95%), 30 kg/t. 2 in enamel kettle, to join the first 350 fuming sulfuric acid, control kettle temperature 0 ~ 5 ℃, under stirring slowly adding nitrobenzene, and keep within 1 h after 132 nitrobenzene kettle temperature to 100 ℃, heat preservation 2 h. Sulfonated sampling test the finish (1 ~ 2 material drops into 10 ml of the test tube containing water, no turbid prove to the finish line). After completion of sulfonation reaction, cooling, slowly in ice water, and in about 3 h add 2 000 salt, hours after salting out, quiet place for the night, suction, pressure dry, intermediate between nitrobenzene sulfonic acid.

Will be between nitrobenzene sulfonic acid into 500 copies of hot water, boil to dissolve. To remove a small amount of sulfone. 50 for soda ash and then add active carbon decoloring, hot filtration, the filtrate cooling crystallization. Filter cake with a small amount of water, under 50 ℃ dry, quick finished product.

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Spironolactone adapt to what are the symptoms?

1. Edema disease with other share, diuretic treatment congestive edema, liver cirrhosis ascites, renal edema, such as edema disease, its aim is to correct the above diseases with increase in the number of secondary aldosterone secretion, and against other diuretic row of potassium. Also used in the treatment of idiopathic edema.

2. High blood pressure effect for auxiliary drug for the treatment of high blood pressure.

3. Primary aldosteronism can be used for the diagnosis and treatment of the disease.

4. Prevention of hypokalemia and thiazide diuretic combination, enhance diuresis effect and prevention of hypokalemia.

Spironolactone in clinically for the treatment of intractable edema associated with elevated aldosterone, therefore is more effective for cirrhosis and nephrotic syndrome patients, and for congestive heart failure unless caused by lack of sodium secondary aldosterone in patients, the effects are poor.

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Mucuna pruriens profile

Mucuna pruriens for annual twining vine. Branches slightly was carried out in thin pilose. Pinnate 3 lobules; Lobules of 6 to 15 cm long or too, 4.5 to 10 cm wide, length, there is little more than half the width of the apical lobule clearly smaller than lateral leaflets, ovoid or elliptical long ovate, base rhombic, apex with a fine point, lateral leaflets extremely skewed, obliquely ovate to lanceolate oval, apex with a fine point, base shallow heart or nearly cross-sectional shape, both sides were white thin thin hairs; Lateral veins usually 5 per side, nearly opposite, raised; Small stipule linear, 4-5 mm long; Petiole 4 -- 9 mm, densely covered with bristles. Raceme prolapse, 12-30 cm long, has more than 10-20 flowers; Bracts small, linear lanceolate; Calyx broadly bell-shaped, densely covered with grayish white pilose and hydrophobic sting, the upper lobes is extremely rich, the lower one middle lobes linear lanceolate, ca. 8 mm long; Corolla purple or white, often shorter, flag 1.6 1.8 cm long, wing disc 2-3.5 cm long, keel 2.8 3.5 (4) cm long. Pods 8-12 cm long, 18 to 20 mm wide, soft fruit, green, densely gray or light brown hair, mature a little flat, black, uplift longitudinal rib 1-2; Seeds 6-8, oblong-elliptic, about 1.5 cm long, ca. 1 cm wide, 5-6 mm thick, gray, yellowish brown, shallow orange or black, sometimes with stripes or spots, hilum ca. 7 mm long, pale yellow white. In October flowering, fruiting in November.

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