Clarithromycin (Limaixian) is a macrolide antibiotic, a new generation of semi synthetic, combined with bacterial cells 50S ribosomal subunit, inhibition of protein synthesis and bacteriostasis to wide, has a strong antimicrobial effect on Gram positive bacteria and Gram-negative bacteria and anaerobic bacteria, is the strongest macrolide antibiotics on the antibacterial activity of Chlamydia and Mycoplasma infection. The activity of clarithromycin against Chlamydia trachomatis in vitro was 7 to 10 times that of erythromycin, which was about 4 times higher than that of doxycycline. The 14 hydroxyl products produced by the metabolism in vivo have biological activity, the antibacterial spectrum is the same as that of clarithromycin, and their antibacterial activity in vivo is greatly improved than that in vitro.
Clarithromycin is a derivative of erythromycin and is suitable for the following infections caused by clarithromycin sensitive bacteria: 1 nasopharyngeal infections: tonsillitis, pharyngitis, sinusitis. 2 lower respiratory tract infection: acute bronchitis, acute exacerbation of chronic bronchitis and pneumonia. 3: skin and soft tissue infections, impetigo, folliculitis, furuncle erysipelas and wound infection. 4 acute otitis media, Mycoplasma pneumoniae pneumonia, Chlamydia trachomatis urethritis and cervicitis. 5 is also used for Legionella infection, or combined with other drugs for the treatment of Mycobacterium avium infection, Helicobacter pylori infection.
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