Mifepristone for the new anti-progesterone, no progesterone, estrogen, androgen and anti-estrogenic activity, with the progesterone receptor and glucocorticoid receptor binding, endometrial progesterone receptor affinity 5 times stronger than progesterone, pregnant animals for each period of pregnancy are abortion effect, can be used as non-surgical anti-pregnancy drugs. In the effective dose had no significant effect on cortisol levels. Because the drug can lead to insufficient uterine activity, anti-pregnancy when used alone incomplete abortion rate is higher, but it can increase the sensitivity of uterine prostaglandins.
Mifepristone also has a role in softening and dilatation of the cervix, it is clinically except for the anti-pregnancy, pregnancy ended after reminders, fetal death, abortion, but also for gynecological surgical procedures, such as the IUD placement and removal, take the inner membrane specimen, cervical dysplasia and cervical dilation and laser separation dilatation and curettage, The oral bioavailability of 70%. Plasma protein binding rate of 98% after 1.5 hours peak blood concentration, the role for 12 hours, eliminating the t1 / 2. Of 18 hours. Generally begin 30 hours after oral administration of vaginal bleeding, continued from 1 to 16 days. Endometrial progesterone receptor affinity five times stronger than progesterone, pregnant animals for each period of pregnancy are abortion effect, can be used as non-surgical anti-pregnancy drugs. IPPF medication is divided into two kinds of birth control pills and anti-pregnancy drug. Taking different doses of mifepristone may achieve different effects, under normal circumstances, each taking 10-25 mg of mifepristone for emergency contraception; taking 150 mg can be terminated within 49 days of pregnancy. Diagnosis of intrauterine pregnancy to the FDA. Menopause generally should not exceed 49 days, pregnancy shorter the better.
More about:Mifepristone sales
From:Hormonehome
No comments:
Post a Comment