Sunday, July 21, 2013

The Testosterone Undecanoate Products




Principle introduced Testosterone Undecanoate
Method name: testosterone undecanoate API - Determination of testosterone undecanoate - spectrophotometry
Application: This method of spectrophotometric determination of testosterone undecanoate drug substance testosterone undecanoate content.
This method is suitable for testosterone undecanoate API.
Principle of the method: the test sample for the test solution add ethanol made, set the UV-visible spectrophotometer at 240nm wavelength absorbance, calculate its content.
Adverse reactions:
In androgen therapy has been found following adverse reactions: prepubertal boys: precocious puberty, increased frequency of erections, penis enlargement and early closure of the epiphyseal bone. Man: priapism and other signs of excessive sexual stimulation, long-term high-dose use may cause decreased sperm, ejaculate volume decreased. All patients: older men urination problems; Shuinazhuliu.
Note:
1 serious adverse reactions, they should immediately stop treatment until the symptoms disappear, and then re-start from a lower dose.
2 Patients who have heart failure (including asymptomatic), renal failure, prostatic hypertrophy, hypertension, epilepsy or trigeminal neuralgia (or have a history of these diseases) caution, should be closely observed, because androgens may cause water and sodium retention.
3 prepubertal boys should be used with caution in order to avoid early epiphyseal closure or precocious puberty.
4 There is a tendency to edema kidney disease, heart disease patients with caution.



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