Clindamycin is a kind of appearance is white crystalline powder chemicals, chemical formula for C18H33ClN2O5S, molecular weight of 424.98300, melting point of 141 ~ 143 ℃. Ingredient of clindamycin phosphate, clindamycin for antibiotic medicine, clinical is mainly used in abdominal cavity and gynecological infections caused by anaerobic bacteria, staphylococcus aureus osteomyelitis is the preferred treatment.
Clindamycin antibacterial spectrum with clindamycin, but strong antimicrobial activity, clindamycin oral absorption quickly and completely (about 90%), eating to absorb the impact is small. [4]. Clindamycin in fetal blood concentration is greater than clindamycin, concentration in milk can be up to 3.8 mu g/ml, pregnant women and lactating women should be paid attention to use the product advantages and disadvantages. High protein binding rate (90%). Oral tmax was 0.75 ~ l hours, T1/2 is 2.4 ~ 3 hours, children of 2 ~ 2.5 hours, when kidney function decline slightly longer, for 3 ~ 5 hours. 24 hours urine by 10%, 3.6% with droppings
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