Sirolimus (INN/USAN), aswell accepted as rapamycin, is an immunosuppressant biologic acclimated to anticipate bounce in agency transplantation; it is abnormally advantageous in branch transplants. It prevents activation of T beef and B beef by inhibiting their acknowledgment to interleukin-2 (IL-2). Sirolimus is aswell acclimated as a coronary stent coating. Sirolimus works, in part, by eliminating old and aberrant white claret cells.[citation needed] Sirolimus is able in mice with autoimmunity and in accouchement with a attenuate action alleged autoimmune lymphoproliferative affection (ALPS).
A macrolide, sirolimus was apparent by Brazilian advisers as a artefact of the bacillus Streptomyces hygroscopicus in a clay sample from Easter Island— an island aswell accepted as Rapa Nui. It was accustomed by the FDA in September 1999 and is marketed beneath the barter name Rapamune by Pfizer (formerly by Wyeth).
Sirolimus was originally developed as an antifungal agent. However, this use was alone if it was apparent to accept almighty immunosuppressive and antiproliferative properties. It has back been apparent to prolong the activity of mice and ability aswell be advantageous in the analysis of assertive cancers.
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