Corticosteroids are made by the adrenal cortex and steroid hormone secretion, also can through the synthetic. Its pharmacological effects and complex, and widely involved in physical systems, such as the stress response, the immune response, and inflammation, carbohydrate metabolism, protein catabolism, control of electrolyte concentration in the blood.
Corticosteroids are cholesterol as raw materials synthesized in the adrenal cortex. Most of the steroid reaction must be catalyzed by cytochrome P450 enzymes. It inside the iron REDOX proteins to mitochondria as a cofactor (except 21 hydroxylase and 17 alpha hydroxylase).
The biosynthetic pathways of aldosterone and corticosterone in the first part of the same, the bottom part respectively by aldosterone synthase and 11 beta hydroxylase intermediary. These two enzymes are very similar, are able to do 11 beta hydroxy and 12 - hydroxy role, but also to 18 - oxidation. In addition, aldosterone synthase exist in the ball of the outside of the adrenal cortex; 11 beta hydroxylase are visible to zona fasciculata and zona.
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