Tetrandrine on animal papillary muscle, from heart and cardiovascular aspects such as the aorta is present different pharmacological effects. The animal experiments found that the drug can reduce the myocardial contraction force, slow cardiac frequency, the expansion of the peripheral blood vessels, reduce the peripheral resistance, reduce cardiac afterload and reduce the myocardial oxygen consumption, inhibition of excited a vascular smooth muscle contraction coupling and relaxation. To animals left atrium muscle contraction frequency dependence and membrane potential dependent inhibition, and have significantly reduced the animal heart strong muscle cell action potential schedule, for the slow response action potential amplitude and time history has obvious inhibitory effect. Through the contrast experiments show that the above function and the effect of slow channel blockers verapamil is extremely similar, this effect was dose and time dependent. When the concentration of 30 umoi/umol/L and 100 L, 100 min after the treatment, slow inward current peak respectively by dosing before 47.9 + / - 5.6 nA and 38.4 + / - 21.5 nA fell to 21 nA + / - 7.8 and 6.3 + / - 7.7 nA, p0.01, R if use Tetrandrine100umol/L of mediated by divalent cations Sr2 + slow inward current also has obvious inhibitory effect. The results suggest that Tetrandrine is a good slow channel blockers.
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