L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs).1 L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.
Appearance: Powder
Physical State: Solid
Solubility: Soluble in 1 N sodium hydroxide or 1N hydrogen chloride; very slightly soluble in water (0.7mg/ml) (ultrasonication). To obtain concentrated solutions, ammonium hydroxide should be added.
Storage: Store at -20° C
Melting Point: >210 °C (dec.)
Boiling Point: 590.16 °C at 760 mmHg (Predicted)
Density: 1.87 g/cm3 (Predicted)
Refractive Index: n20D 1.82 (Predicted)
L-Biopterin is an important cofactor in the production of many essential neurotransmitters, such as dopamine, seratonin and epinephrine, and plays an important role in the production of nitric oxide in the body. It is produced as an oxidation product by the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). L-Biopterin has been shown to be cytotoxic to melanocytes in vitro, and may be a useful noninvasive biomarker.
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