Management of hypertension (alone or in combination with other antihypertensive agents).
Slideshow: Grapefruit and Medicines - A Possible Deadly Mix?
Grapefruit and Medicines - A Possible Deadly Mix?
Grapefruit and grapefruit juice can react adversely with over 85 prescription medications.
Most experience with combination therapy to date has been with diuretics, an angiotensin II receptor antagonist (valsartan), or a calcium-channel blocking agent (amlodipine); concomitant use of aliskiren with any of these drugs at maximum recommended dosages produces a greater BP response than does use of each drug alone.
Not known whether effects of aliskiren and ACE inhibitors or aliskiren and β-adrenergic blocking agents are additive.1 Whether aliskiren further improves BP control in patients receiving maximum dosages of an ACE inhibitor not established.1
Use in combination with an ACE inhibitor or angiotensin II receptor antagonist is contraindicated in diabetic patients and is not recommended in patients with moderate or severe renal impairment (GFR <60 mL/minute).
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