Ethinyl estradiol is 3 - hydroxy-19 - demethyl-17α-pregna-1, 3,5 (10) - triene-20 - alkynyl -17 - ol. Calculated on dry goods, including C20H24O2 should be 97.0% ~ 103.0%. White or almost white crystalline powder; odorless. This product is ethanol, propanol or ether soluble, dissolved in chloroform, insoluble in water. The product of the melting point (Appendix Ⅵ C) to 180 ~ 186 ℃.
Indications:
⒈ estrogen deficiency, treatment of female gonadal dysfunction, amenorrhea, menopausal syndrome, etc.; for advanced breast cancer (postmenopausal women), the treatment of advanced prostate cancer; drugs in combination with progesterone, can inhibit ovulation, can be used for contraceptives. The main clinical medicine as inhibiting ovulation; also used in pediatric cryptorchidism and androgen excess, pituitary tumors. For the diagnosis of hypothalamic - pituitary - gonadal dysfunction, according to which changes in gonadotropin and sex hormone levels.
⒉ treatment due to inadequate secretion of gonadotropin hypogonadism amenorrhea and infertility, infertility multiple ovarian follicles. Amenorrhea associated with weight loss, should be corrected with diet weight. Also used for prostate cancer (often with cyproterone or fluorine carboximide combined), delayed puberty or early and endometrial bit different. Mainly used in suppressing ovulation to achieve the purpose of contraception.
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From:Hormonehome
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