Sulfa drugs for the broad spectrum antibacterial agents, similar in structure to para-aminobenzoic acid (PABA), PABA competitive action with the bacterial two-synthase in vivo, thereby preventing bacteria PABA synthesis required for the process of folic acid, reduced folate metabolic activity with the amount, while the latter is a bacterial purine synthesis, thymidine, and DNA (DNA) of the necessary material, thus inhibiting bacterial growth and reproduction. Sulfa drugs action can be PABA and its derivatives (procaine, tetracaine) antagonized, in addition pus and the organization of the existence of decomposition products from the antagonism, because it provides the necessary material for bacterial growth.
Sulphadimidine is an antibacterial sulfa drugs; induction of CYP3A4 expression, and by N-acetyl transferase acetylation; exhibit pharmacokinetics of dependence, by means of the male specific isoforms metabolize CYP2C11; inhibit dihydrofolate synthesis enzymes, to hinder the effect of folate synthesis. With sulfadiazine equivalent effect. For the treatment of hemolytic streptococcus, meningococcus, pneumococcus infections, lasting.
As a feed additive for the prevention of hemolytic streptococcus and staphylococcus infections, where the main treatment of fowl cholera, fowl typhoid, coccidiosis and so on.
For the control of Staphylococcus and Streptococcus infections solubility of hemolytic streptococcus and other bacteria are inhibited pleurisy bacteria, the main treatment of fowl cholera, fowl typhoid, coccidiosis, etc.
As antibacterial agents for the prevention of hemolytic streptococcus and staphylococcus infections, for the treatment of hemolytic streptococcus, meningococcus, pneumococcus infections. Primarily for the treatment of fowl cholera, fowl typhoid, coccidiosis and so on.
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