What is the Levosimendan? There's a lot of people who don't know about it, and here's the introduction:
Levosimendan is a yellow or orange transparent liquid. This product is a sterilized anhydrous ethanol solution, which contains hydroxypropyl cyclodextrin and anhydrous citric acid.
Levosimendan directly combined with troponin, necessary to make the myocardial contraction induced by calcium ion to stability, space configuration of myocardial fibers of the protein to increase myocardial contraction force, and the heart rate, myocardial oxygen consumption has no obvious change. At the same time, this product has strong expansion blood vessel, through activation of adenosine triphosphate (ATP) sensitive potassium channels expand blood vessels, this article mainly expand peripheral vein, reduce cardiac preload, good for treatment of heart failure. When large dosage is used, it has certain phosphodiesterase inhibition, which can increase the cAMP concentration in myocardial cells and exert an additional positive effect.
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