What are the role of Nizatidine

Nizatidine is a kind of sexual selection antagonist medicine, mainly used for the treatment and prevention of gastric and duodenal ulcer.

Nizatidine for H2 receptor blockers. Animal studies have shown that by the stimulation such as histamine, gastric secrete element and things caused by inhibition of gastric acid secretion than cimetidine for Ding Jiang 8.9 times its antiulcer effect than cimetidine for Ding Jiang 3 ~ 4 times, and are similar to those of ranitidine. Clinical studies have demonstrated that this product can significantly inhibit gastric acid secretion for 12 hours at night. 1 oral healthy subjects 300 mg, inhibition of gastric acid secretion at night an average of 90%, 10 hours after gastric acid secretion is still down 52%. Oral 【 75 ~ 300 mg does not affect the activity of pepsin in stomach secretions, pepsin total to reduce the secretion of gastric secretion volume reduced in proportion. Serum gastric secrete element or for basic food caused by high blood stomach gastrin-releasing little role; 12 hours after giving this product feeding, did not see the stomach secrete hormone is bounce. This product has no resistance to androgen effects. Oral this product after the absolute bioavailability of more than 90%, to 150 mg or 300 mg, Cmax is 700 ~ 1800 mu g/L and 1400 ~ 3600 mu g/L, t Max 0.5 ~ 5 hours, 12 hours after the treatment the blood drug concentration below 10 mu g/L; T1/2 beta is 1 ~ 2 hours, Vd is 0.8 ~ 1.5 L/kg, CL is 40 ~ 60 L/h, oral 150 mg AUC 314.6 (mu g h.)/ml. Due to the short half-life, clear quickly, the accumulation of individual normal renal function is generally not happen. This product more than 90% of the oral dose within 12 hours with the urine excretion, less than 6% of doses with fecal excretion, about 60% of the oral dose excreted unchanged; By renal tubular secretion and excretion, the CLr is 500 ml/min, to moderate in renal dysfunction significantly longer half-life and reduce clearance. Plasma protein conjugation rate is about 35%.

Activity of endoscopy confirmed duodenal ulcer patients, results were compared with the placebo double-blind experiments show that this product can make the ulcer healing. Taking this product 150 mg before bed can make the duodenal ulcer recurrence rate is decreased obviously.

Used in active treatment of duodenal and benign gastric ulcer, course of 8 weeks; Can also be used for duodenal ulcer healing for prevention.