Pirenzepine, as a kind of selective anticholinergic drugs, cells of the stomach variety of alkali receptors with high affinity, and for smooth muscle, cardiac muscle and salivary glands and other variety of alkali receptor affinity is low, so the application of general treatment doses, only can inhibit the secretion of gastric acid, and there are few other choline drug resistance to the pupil, gastrointestinal smooth muscle, heart, salivary glands and bladder muscle and other side effects. Doses can inhibit the production of saliva, only large doses can inhibit gastrointestinal smooth muscle and causes tachycardia.
Pirenzepine is mainly used in the treatment of gastric and duodenal ulcer, and can obviously relieve patients' pain, reduce the dosage of antacids. Recent ulcer healing rate at about 70% one 94%, curative effect and cimetidine, is better than that of carbenoxolone sodium. With cimetidine share can enhance the effect of the inhibition of gastric acid secretion. [usage and dosage] adult commonly used oral doses of 50 mg, 1, 2, early take one and a half hours before dinner. Treatment with 4-6 Zhou Weiyi. Severe cases, 1, volume can be increased to 150 mg, three times. Require long-term treatment of patients, may be for 3 months.
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