Obeticholic Acid method, alcohol X agonists, through X receptor activation method, alcohol, indirect inhibit cytochrome 7 a1 (CYP7A1) gene expression. Since CYP7A1 is the speed limit of bile acid biosynthesis enzyme, so the bei cholic acid can inhibit the bile acid synthesis, used in the treatment of primary biliary cirrhosis and non-alcoholic fatty liver disease.
Obeticholic Acid method, alcohol X agonists, through X receptor activation method, alcohol, indirect inhibit cytochrome 7 a1 (CYP7A1) gene expression. Since CYP7A1 is the speed limit of bile acid biosynthesis enzyme, so the bei cholic acid can inhibit the bile acid synthesis, used in the treatment of primary biliary cirrhosis and non-alcoholic fatty liver disease.
Obeticholic Acid Intercept by the United States pharmaceutical companies to develop successful, is the first twenty years of research and development for the treatment of cholestasis liver disease drugs. Research on the old standard treatment for those who bear bile acid is not fully response to oxygen or intolerance to the patients. Placebo-controlled phase iii trial, Mr Berlusconi cholic acid (OCA) increased with two biomarkers related to lower risk of liver transplantation. Clinical research of the composite end point is at least by 15% of alkaline phosphatase, serum alkaline phosphatase activity of 1.67 times lower than the normal limit, and bilirubin in the normal range, alkaline phosphatase was used to represent a kind of the severity of liver disease biomarkers.
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