Camostat hydrolyze rapidly, prototype drug blood concentration in rats and very low per capita. Absorb quickly, this article take orally after dosing 40 min, the active metabolite 4 - (4 - guanidine benzoyl oxygen radicals) phenylacetic acid which reached the peak of my blood drug concentration (84 ng/ml). 40 ~ 80 min after the treatment the blood concentration peak, in vitro of trypsin and plasma kallikrein ID50 value can be maintained for about 5 hours. Blood has a half-life of 73 min, within 5 ~ 6 h after drug excretion from urine was 20%, most of the metabolites in urine for 4 - guanidine benzoic acid, its a small amount of 4 - http://www.pharmaceutiucal-materials.com/Pharmaceutica-Raw-Materials/Camostat/ low toxicity, big mouse oral LD50 of about 3000 mg/kg. Subacute and chronic toxicity test, this product can increase the weight of pancreas, make acinar cell hypertrophy, enzyme original particles increases, but stop most animals can recover after the treatment. About reproductive toxicity test on rats the Seg I, Seg II test, this product can make the matrix hypertrophy of the pancreas, but does not affect the fetus; In Seg III trials found that this product can inhibit the newborn's growth. Mutagenic tests were negative.
Camostat hydrolyze rapidly, prototype drug blood concentration in rats and very low per capita. Absorb quickly, this article take orally after dosing 40 min, the active metabolite 4 - (4 - guanidine benzoyl oxygen radicals) phenylacetic acid which reached the peak of my blood drug concentration (84 ng/ml). 40 ~ 80 min after the treatment the blood concentration peak, in vitro of trypsin and plasma kallikrein ID50 value can be maintained for about 5 hours. Blood has a half-life of 73 min, within 5 ~ 6 h after drug excretion from urine was 20%, most of the metabolites in urine for 4 - guanidine benzoic acid, its a small amount of 4 - http://www.pharmaceutiucal-materials.com/Pharmaceutica-Raw-Materials/Camostat/ low toxicity, big mouse oral LD50 of about 3000 mg/kg. Subacute and chronic toxicity test, this product can increase the weight of pancreas, make acinar cell hypertrophy, enzyme original particles increases, but stop most animals can recover after the treatment. About reproductive toxicity test on rats the Seg I, Seg II test, this product can make the matrix hypertrophy of the pancreas, but does not affect the fetus; In Seg III trials found that this product can inhibit the newborn's growth. Mutagenic tests were negative.
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