What drug effective for neuron disease

　　The Riluzole , its chemical name is: 2 - amino - 6 - trifluoro methoxy benzothiazole. This product is white or kind of white. For the treatment of muscle atrophy in patients with amyotrophic lateral sclerosis, can prolong the survival time and/or delay of trachea incision.
　　Amyotrophic lateral sclerosis (ALS) or motor neurone disease is a progressive fatal disease. There are two kinds of form: the disease pathogenesis or medulla oblongata of the body. Both of upper and lower motor neuron loss, resulting in progressive and irreversible muscle wasting and weakness. Although the disease pathogenesis is not yet fully understand, glutamate toxicity is a possible cause of the neuron damage. So now will be able to adjust in glutamate levels in the central nervous system drugs as a possible cure.
　　Benzothiazole drugs,Riluzole is this kind of drug glutamic acid, nerve protection mechanism is complex, involving several different process. Already know is that it can inhibit the presynaptic glutamate release and can prevent glutamate and receptor activation. This product also can make the nerve endings and the potentials of the dependence of sodium channel inactivation, stimulate dependent on G protein signal transduction process.

　　In vitro, this product can protect the cultured motor neurons from the toxic effects of glutamic acid activation, and prevent the ALS patients due to lack of oxygen or exposed to toxic factors in the CSF of lead to neuronal death. In the mouse model of spinal motor neuron degeneration, this product can improve its mobility.